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A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
TLDR
Case-control analyses showed that a six-nucleotide deletion in the CASP8 promoter is associated with reduced susceptibility to multiple cancers, including lung, esophageal, gastric, colorectal, cervical and breast cancers, acting in an allele dose–dependent manner.
Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer.
TLDR
Findings indicate that genetic variants in COX-2 may play a role in mediating susceptibility to esophageal cancer.
Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer.
TLDR
It is found that genetic polymorphisms influencing T-cell activation modify cancer susceptibility, and the 49G>A polymorphism in the CTLA-4 leading sequence causing (17)Ala to ( 17)Thr amino acid substitution is associated with increased susceptibility to multiple cancers, including lung, breast, esophagus, and gastric cardia cancers.
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
TLDR
Results suggest that genetic variants in 3q28, 5p15.33, 13q 12.12 and 22q12.2 may contribute to the susceptibility of lung cancer in Han Chinese.
Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer
TLDR
In conclusion, genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 contribute to the risk of developing lung cancer.
Circulating MicroRNAs, miR‐21, miR‐122, and miR‐223, in patients with hepatocellular carcinoma or chronic hepatitis
TLDR
Serum miRNAs presented in serum of patients with HCC and chronic hepatitis have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC, according to Receiver‐operator characteristic (ROC) curve analyses.
A novel T-77C polymorphism in DNA repair gene XRCC1 contributes to diminished promoter activity and increased risk of non-small cell lung cancer
TLDR
The results showed that the functional SNP −77T>C in XRCC1 5′UTR was associated with cancer development owing to the decreased transcriptional activity of C-allele-containing promoter with higher affinity to Sp1 binding.
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
TLDR
A genome-wide association study in 3,279 individuals of Chinese descent found two new susceptibility loci for non-cardia gastric cancer at 5p13.1 and 3q13.31, and confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non- Cardia gastrics cancer susceptibility in the Han Chinese population.
Identification of Genetic Variants in Base Excision Repair Pathway and Their Associations with Risk of Esophageal Squamous Cell Carcinoma
TLDR
The results suggest that the polymorphisms in five BER genes may be associated with the susceptibility to ESCC in a Chinese population.
Substantial reduction in risk of lung adenocarcinoma associated with genetic polymorphism in CYP2A13, the most active cytochrome P450 for the metabolic activation of tobacco-specific carcinogen NNK.
TLDR
It is demonstrated for the first time that the variant CYP2A13 allele is associated with reduced risk of lung adenocarcinoma, suggesting the role of NNK-CYP2A 13 interaction as a causative factor for the cancer.
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