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A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes
We present rna22, a method for identifying microRNA binding sites and their corresponding heteroduplexes. Rna22 does not rely upon cross-species conservation, is resilient to noise, and, unlikeExpand
Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State
It is shown that coexpression of Slug and Sox9 promotes the tumorigenic and metastasis-seeding abilities of human breast cancer cells and is associated with poor patient survival, providing direct evidence that human breast cancers stem cells are controlled by key regulators similar to those operating in normal murine MaSCs. Expand
The epigenetics of epithelial-mesenchymal plasticity in cancer
During the course of malignant cancer progression, neoplastic cells undergo dynamic and reversible transitions between multiple phenotypic states, the extremes of which are defined by the expressionExpand
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1
It is demonstrated that Sall4 is a transcriptional activator of Pou5f1 and has a critical role in the maintenance of ES cell pluripotency by modulating Oct4 expression, and indicates that SAll4 is important for early embryonic cell-fate decisions. Expand
XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway
It is reported that XBP1 is activated in TNBC and has a pivotal role in the tumorigenicity and progression of this human breast cancer subtype, and targeting this pathway may offer alternative treatment strategies for this aggressive subtype of breast cancer. Expand
Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells
A positive and potentially self-reinforcing regulatory loop that maintains Pou5f1 and Sox2 expression via the Oct4/Sox2 complex in pluripotent cells is uncovered. Expand
Distinct EMT programs control normal mammary stem cells and tumour-initiating cells
It is shown that normal gland-reconstituting mammary stem cells residing in the basal layer of the mammary epithelium and breast TICs originating in the luminal layer exploit the paralogous EMT-TFs Slug and Snail, respectively, which induce distinct EMT programs. Expand
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.
It is demonstrated that a single transcription factor is able to regulate distinct core circuitries in two different blastocyst-derived stem cell lines, embryonic stem cells (ESCs) and extraembryonic endoderm (XEN) cells. Expand
Tbx3 improves the germ-line competency of induced pluripotent stem cells
iPS cells generated with OSK and Tbx3 (OSKT) are superior in both germ-cell contribution to the gonads and germ-line transmission frequency, and the need to rigorously characterize iPS cells beyond in vitro studies is highlighted. Expand
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
It is shown that tumour-associated monocytes and macrophages create a CSC niche through juxtacrine signalling with CSCs through upregulating the expression of CD90 and EphA4, which mediate the physical interactions of C SCs with TAMs by directly binding with their respective counter-receptors on these cells. Expand