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The EGF-CFC Protein One-Eyed Pinhead Is Essential for Nodal Signaling
- K. Gritsman, Jiaojiao Zhang, Simon K Cheng, E. Heckscher, W. Talbot, A. Schier
- Biology, Medicine
- 2 April 1999
It is reported that embryos lacking both maternal and zygotic Oep activity are defective in germ layer formation, organizer development, and the positioning of the anterior-posterior axis. Expand
erbb3 and erbb2 Are Essential for Schwann Cell Migration and Myelination in Zebrafish
In vivo evidence is provided that Neuregulin-ErbB signaling is essential for directed Schwann cell migration and it is demonstrated that this pathway is also required for the onset of myelination in postmigratory Schwann cells. Expand
Zebrafish organizer development and germ-layer formation require nodal-related signals
It is reported that the zebrafish squint (sqt) and cyclops (cyc) genes have essential, although partly redundant, functions in organizer development and also in the formation of mesoderm and endoderm. Expand
The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis.
The studies demonstrate that the molecular mechanisms that regulate hematopoietic and vasculogenic cells in normal zebrafish have been conserved throughout vertebrate evolution and the clo and spt genes are key regulators of these programs. Expand
Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms
This work uses isoform-specific monoclonal antibodies to show that at the onset of metamorphosis different ecdysone target tissues express different isoform combinations in a manner consistent with the proposition that the different metamorphic responses of these tissues require different combinations of the EcR isoforms. Expand
A homeobox gene essential for zebrafish notochord development
It is shown that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord, and it is proposed that flh regulates notochords precursor cell fate. Expand
The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
- M. Koelle, W. Talbot, W. Segraves, M. Bender, P. Cherbas, D. Hogness
- Medicine, Biology
- 4 October 1991
The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue development that result in metamorphosis and a gene, EcR, is isolated and characterized for a new steroid receptor homolog and it is shown that it encodes an ecDysone receptor. Expand
Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.
It is reported that mouse mutants for lefty2 have an expanded primitive streak and form excess mesoderm, a phenotype opposite to that of mutants for the TGF beta gene nodal, a feedback loop wherein Nodal signals induce their antagonists Lefty2 and Antivin to restrict NodAl signaling during gastrulation. Expand
The zebrafish gene map defines ancestral vertebrate chromosomes.
It is found that different duplicated genes have been retained in zebrafish and Tetraodon, although similar numbers of duplicates remain in both genomes, and the proposal that the common ancestor of vertebrates had a genome consisting of 12 chromosomes is addressed. Expand
Molecular genetics of axis formation in zebrafish.
The basic vertebrate body plan of the zebrafish embryo is established in the first 10 hours of development, and how the coordinated interplay of molecules determines the fate and movement of embryonic cells is reviewed. Expand