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Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication.
OPN (osteopontin)) is a Hh (Hedgehog)-regulated cytokine that is up-regulated during chronic liver injury and directly promotes fibrosis. We have reported that Hh signalling enhances viral… Expand
Thyroid Hormone receptor regulates hepatic stellate cell activation
Amitriptyline Inhibits Nonalcoholic Steatohepatitis and Atherosclerosis Induced by High-Fat Diet and LPS through Modulation of Sphingolipid Metabolism.
- Z. Lu, Y. Li, +4 authors Y. Huang
- Chemistry, Medicine
- American journal of physiology. Endocrinology and…
- 10 December 2019
We reported previously that increased acid sphingomyelinase (ASMase)-catalyzed hydrolysis of sphingomyelin, which leads to increases in ceramide and sphingosine 1 phosphate (S1P), played a key role… Expand
Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?
- M. Morrison, Heather Y Hughes, S. Naggie, W. Syn
- Digestive Diseases and Sciences
- 23 October 2019
Liver disease is a leading cause of non-AIDS-related death in the HIV population since the introduction of highly active antiretroviral treatment (HAART). Recent studies suggest that patients with… Expand
The Emerging Epidemic of Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: True, True, and Related?
Nonalcoholic fatty liver disease (NAFLD), a condition that affects over 30% of Americans, is one of the leading indications for liver transplantation. The prevalence of NAFLD has paralleled the… Expand
The role of osteopontin isoforms in cholangiocarcinoma
firstname.lastname@example.org https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of… Expand
O‐19: Towards a bivalent prophylactic vaccine against hepatitis B and C viruses?
mTORC1 is a novel HCV host factor S Stöhr, R Costa, L Sandmann, S Westhaus, S Pf€ ander, E Dazert-Klebsattel, MP Manns, E Steinmann, T von Hahn and S Ciesek Hannover Medical School, Gastroenterology,… Expand
379 THREE PHENOTYPICALLY AND FUNCTIONALLY DISTINCT MONOCYTE SUBSETS AND THEIR ROLE IN HUMAN LIVER FIBROSIS
PMO-121 Osteopontin promotes natural killer T (NKT) cell accumulation in nonalcoholic steatohepatitis (NASH)
Introduction Progressive steatohepatitis is characterised by increased inflammatory cell infiltration. Osteopontin (OPN) is a cytokine intricately associated with immune-cell accumulation, and we… Expand
PTU-113 Osteopontin is involved in chronic HBV infection and enhances HBV replication and HBSAG secretion
Introduction Hepatitis B virus (HBV) requires host cellular machinery such as cyclophilins to support its ongoing propagation (Phillips et al , Gastroenterology 2014) these host proteins represent… Expand