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Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication.
OPN (osteopontin)) is a Hh (Hedgehog)-regulated cytokine that is up-regulated during chronic liver injury and directly promotes fibrosis. We have reported that Hh signalling enhances viralExpand
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Amitriptyline Inhibits Nonalcoholic Steatohepatitis and Atherosclerosis Induced by High-Fat Diet and LPS through Modulation of Sphingolipid Metabolism.
  • Z. Lu, Y. Li, +4 authors Y. Huang
  • Chemistry, Medicine
  • American journal of physiology. Endocrinology and…
  • 10 December 2019
We reported previously that increased acid sphingomyelinase (ASMase)-catalyzed hydrolysis of sphingomyelin, which leads to increases in ceramide and sphingosine 1 phosphate (S1P), played a key roleExpand
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Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?
Liver disease is a leading cause of non-AIDS-related death in the HIV population since the introduction of highly active antiretroviral treatment (HAART). Recent studies suggest that patients withExpand
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The Emerging Epidemic of Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: True, True, and Related?
Nonalcoholic fatty liver disease (NAFLD), a condition that affects over 30% of Americans, is one of the leading indications for liver transplantation. The prevalence of NAFLD has paralleled theExpand
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The role of osteopontin isoforms in cholangiocarcinoma
eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 ofExpand
O‐19: Towards a bivalent prophylactic vaccine against hepatitis B and C viruses?
mTORC1 is a novel HCV host factor S Stöhr, R Costa, L Sandmann, S Westhaus, S Pf€ ander, E Dazert-Klebsattel, MP Manns, E Steinmann, T von Hahn and S Ciesek Hannover Medical School, Gastroenterology,Expand
PMO-121 Osteopontin promotes natural killer T (NKT) cell accumulation in nonalcoholic steatohepatitis (NASH)
Introduction Progressive steatohepatitis is characterised by increased inflammatory cell infiltration. Osteopontin (OPN) is a cytokine intricately associated with immune-cell accumulation, and weExpand
PTU-113 Osteopontin is involved in chronic HBV infection and enhances HBV replication and HBSAG secretion
Introduction Hepatitis B virus (HBV) requires host cellular machinery such as cyclophilins to support its ongoing propagation (Phillips et al , Gastroenterology 2014) these host proteins representExpand