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LC/MS/MS quantitation assay for pharmacokinetics of naringenin and double peaks phenomenon in rats plasma.
TLDR
The results showed that there was a linear relationship between the AUC of total NAR and dosages and the double peaks are mainly due to enterohepatic circulation. Expand
Immuno-enhancement effects of Shenqi Fuzheng Injection on cyclophosphamide-induced immunosuppression in Balb/c mice.
TLDR
It is demonstrated, for the first time, that chronic treatment with SFI results in accelerating recovery of immunosuppression in Cy-treated mice, which is competent in taking into consideration for both precautions and remedy. Expand
Composition and variability of essential oils of Platycladus orientalis growing in China
TLDR
Chemical variability in essential oil composition was evaluated using cluster analysis and principal component analysis and led to the identification of four chemotypes: α-pinene, α- pinene/3-carene, cedrol, and cEDrol/terpinyl acetate. Expand
AlzPlatform: An Alzheimer’s Disease Domain-Specific Chemogenomics Knowledgebase for Polypharmacology and Target Identification Research
TLDR
The AlzPlatform will enrich knowledge for AD target identification, drug discovery, and polypharmacology analyses and, also, facilitate the chemogenomics data sharing and information exchange/communications in aid of new anti-AD drug discovery and development. Expand
TargetHunter: An In Silico Target Identification Tool for Predicting Therapeutic Potential of Small Organic Molecules Based on Chemogenomic Database
TLDR
A new web-based target prediction tool, TargetHunter, that provides a promising alternative to bridge the knowledge gap between biology and chemistry, and significantly boost the productivity of chemogenomics researchers for in silico drug design and discovery is described. Expand
Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study.
TLDR
The value of R b(1) is higher than that of Rb(2) or Rb (3), indicating that ginsenosides with hexose and hydroxyl groups (Rb(1)) could present better pharmacokinetic behaviors than those with pentose groups in the same glycosylation site by oral administration. Expand
Hepatoprotective effect of Hypericum japonicum extract and its fractions.
TLDR
Different fractions of Hypericum japonicum manifest different effect, indicating their different potentials as candidacies of new drugs, and chemical fingerprint indicated that F5 contained several flavonoids which might be the active chemicals against hepatotoxicity. Expand
A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells
TLDR
THSG significantly increased the activity of murine tyrosinase and stimulated melanin biosynthesis in B16 melanoma cells, indicating potential for the treatment of hypopigmentation disease. Expand
Pharmacokinetics and Metabolism of Naringin and Active Metabolite Naringenin in Rats, Dogs, Humans, and the Differences Between Species
TLDR
The results show an insignificant influence of high-fat diet and insignificant accumulation of the drugs after multiple dosing of naringin and naringenin, which can be used to design a dosage regimen, deepen understanding of mechanisms, and accelerate new drug development. Expand
A rapid LC/MS/MS quantitation assay for naringin and its two metabolites in rats plasma.
TLDR
Plasma concentration-time profiles of naringin were found to increase quickly and decline rapidly within 2 h and could not be detected after 24 h and a highly sensitive and specific electrospray ionization (ESI) liquid chromatography-tandem mass spectrometry (LC/MS/MS) method was developed for quantification. Expand
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