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Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.
Fluorescence-guided resection of glioblastoma multiforme by using 5-aminolevulinic acid-induced porphyrins: a prospective study in 52 consecutive patients.
- W. Stummer, A. Novotny, H. Stepp, C. Goetz, K. Bise, H. Reulen
- MedicineJournal of neurosurgery
- 1 December 2000
The usefulness of 5-ALA-induced tumor fluorescence for guiding tumor resection on postoperative magnetic resonance (MR) imaging and survival in patients who underwent surgery in the authors' department is indicated.
Intraoperative detection of malignant gliomas by 5-aminolevulinic acid-induced porphyrin fluorescence.
It is suggested that 5-aminolevulinic acid-induced porphyrin fluorescence may label malignant gliomas safely and accurately enough to enhance the completeness of tumor removal.
EXTENT OF RESECTION AND SURVIVAL IN GLIOBLASTOMA MULTIFORME: IDENTIFICATION OF AND ADJUSTMENT FOR BIAS
The present data provide Level 2b evidence (Oxford Centre for Evidence-based Medicine) that survival depends on complete resection of enhancing tumor in glioblastoma multiforme and treatment bias was demonstrated regarding resection and second-line therapies.
Technical Principles for Protoporphyrin-IX-Fluorescence Guided Microsurgical Resection of Malignant Glioma Tissue
- W. Stummer, H. Stepp, G. Möller, A. Ehrhardt, M. Leonhard, H. Reulen
- MedicineActa Neurochirurgica
Tissue detail is great enough to enable tumour resection under violet-blue excitation light during parts of the operation, and the system appears to constitute a useful tool for optimizing removal of malignant gliomas on a routine basis.
5-Aminolevulinic Acid-derived Tumor Fluorescence: The Diagnostic Accuracy of Visible Fluorescence Qualities as Corroborated by Spectrometry and Histology and Postoperative Imaging
Fluorescence appears superior to contrast enhancement on MRI for indicating residual tumor and spectrometry, on the other hand, is more sensitive but less specific, depending on threshold definition.
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy.
In patients with intracerebral lesions supposed to be diffuse gliomas on MR imaging, FET-PET and MR spectroscopy analyses markedly improved the diagnostic efficacy of targeted biopsies.
Glioblastoma multiforme of the elderly: the prognostic effect of resection on survival
- C. Ewelt, M. Goeppert, M. Rapp, H. Steiger, W. Stummer, M. Sabel
- MedicineJournal of Neuro-Oncology
- 1 July 2011
It is shown that elderly GBM patients can benefit from maximum treatment procedures with cytoreductive microsurgery, radiation therapy, and chemotherapy, and should not be per se excluded from intensive treatment procedures.
Resection and survival in glioblastoma multiforme: an RTOG recursive partitioning analysis of ALA study patients.
Differences in survival depending on resection status, especially in RPA classes IV and V, support a causal influence of resection on survival.
Comparison of 18F-FET PET and 5-ALA fluorescence in cerebral gliomas
18F-FET PET is more sensitive to detect glioma tissue than 5-ALA fluorescence and should be considered as an additional tool in resection planning due to a limited sensitivity of 5- ALA to detect tumour tissue especially in LGG.