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The pharmacophore of short cationic antibacterial peptides.
Cationic antibacterial peptides have been proclaimed as new drugs against multiresistant bacteria. Their limited success so far is partially due to the size of the peptides, which gives rise toExpand
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Important structural features of 15-residue lactoferricin derivatives and methods for improvement of antimicrobial activity.
This review focuses on important structural features affecting the antimicrobial activity of 15-residue derivatives of lactoferricins. Our investigations are based on an alanine-scan of a 15-residueExpand
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Bulky nonproteinogenic amino acids permit the design of very small and effective cationic antibacterial peptides.
The rate of multidrug-resistant infections is rapidly rising. Cationic antibacterial peptides are active against resistant pathogens and have low propensity for resistance development, but because ofExpand
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Enhanced antitumor activity and selectivity of lactoferrin-derived peptides.
A number of peptide analogs derived from the N-terminal alpha-helical region of bovine lactoferrin (LFB 14-31), were designed in order to investigate how deviating numbers and positions of positivelyExpand
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High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms.
OBJECTIVES The aim of the study was to investigate the antimicrobial effect of different antibiotics and synthetic antimicrobial peptidomimetics (SAMPs) on staphylococcal biofilms. METHODS BiofilmsExpand
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Increased antibacterial activity of 15-residue murine lactoferricin derivatives.
LFM W8 is a synthetic 15-residue lactoferricin derivative (H2N-EKCLRWQWEMRKVGG-COOH), corresponding to residues 16-30 of the mature murine lactoferrin protein except that the asparagine residue inExpand
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A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption.
LTX 109 is a synthetic antimicrobial peptidomimetic (SAMP) currently in clinical phase II trials for topical treatment of infections of multiresistant bacterial strains. All possible eightExpand
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Antimicrobial peptides with stability toward tryptic degradation.
The inherent instability of peptides toward metabolic degradation is an obstacle on the way toward bringing potential peptide drugs onto the market. Truncation can be one way to increase theExpand
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Antifouling compounds from the sub-arctic ascidian Synoicum pulmonaria: synoxazolidinones A and C, pulmonarins A and B, and synthetic analogues.
The current study describes the antifouling properties of four members belonging to the recently discovered synoxazolidinone and pulmonarin families, isolated from the sub-Arctic sessile ascidianExpand
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Structural determination of 1,4‐naphthoquinones by mass spectrometry/mass spectrometry
The fragmentation pathways of several substituted 1,4-naphthoquinones have been studied by multi stage mass spectrometry. Methods for the recognition and identification of 1,4-naphthoquinones and ofExpand
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