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- Publications
- Influence
NO-independent regulatory site on soluble guanylate cyclase
- Johannes-Peter Stasch, E. Becker, +13 authors M. Schramm
- Biology, Medicine
- Nature
- 8 March 2001
Nitric oxide (NO) is a widespread, potent, biological mediator that has many physiological and pathophysiological roles. Research in the field of NO appears to have followed a straightforward path,… Expand
NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle
- J. Stasch, P. Schmidt, +13 authors F. Wunder
- Biology, Medicine
- British journal of pharmacology
- 1 July 2002
Soluble guanylyl cyclase (sGC) is the only proven receptor for the ubiquitous biological messenger nitric oxide (NO) and is intimately involved in many signal transduction pathways, most notably in… Expand
Finerenone, a Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Protects From Rat Cardiorenal Injury
- P. Kolkhof, M. Delbeck, +6 authors S. Schäfer
- Medicine
- Journal of cardiovascular pharmacology
- 1 July 2014
Abstract: Pharmacological blockade of the mineralocorticoid receptor (MR) ameliorates end-organ damage in chronic heart failure. However, the clinical use of available steroidal MR antagonists is… Expand
BAY 1000394, a Novel Cyclin-Dependent Kinase Inhibitor, with Potent Antitumor Activity in Mono- and in Combination Treatment upon Oral Application
- G. Siemeister, U. Lücking, +5 authors K. Ziegelbauer
- Biology, Medicine
- Molecular Cancer Therapeutics
- 19 July 2012
Deregulated activity of cyclin-dependent kinases (CDK) results in loss of cell-cycle checkpoint function and increased expression of antiapoptotic proteins, which has been directly linked to the… Expand
Artemisone--a highly active antimalarial drug of the artemisinin class.
- R. Haynes, B. Fugmann, +23 authors A. Roemer
- Chemistry, Medicine
- Angewandte Chemie
- 20 March 2006
Artemisinin - the next generation: Efficacies of artemisone against the malaria parasite are substantially greater than those of the current artemisinin "gold standard", artesunate. Also, in contrast… Expand
Pharmacokinetics of miglitol. Absorption, distribution, metabolism, and excretion following administration to rats, dogs, and man.
- H. Ahr, M. Boberg, E. Brendel, H. Krause, W. Steinke
- Chemistry, Medicine
- Arzneimittel-Forschung
- 1 June 1997
The absorption, distribution, metabolism, and excretion of miglitol ((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)-3,4,5-piperidinet riol, CAS 72432-03-2, BAY m 1099) have been studied following… Expand
NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272
- E. Becker, C. Alonso-Alija, +10 authors Johannes-Peter Stasch
- Medicine, Chemistry
- BMC pharmacology
- 28 December 2001
BackgroundThe most important receptor for nitic oxide is the soluble guanylate cyclase (sGC), a heme containing heterodimer. Recently, a pyrazolopyridine derivative BAY 41-2272, structurally related… Expand
Pharmacokinetics of BAY 59-7939 – an oral, direct Factor Xa inhibitor – in rats and dogs
- C. Weinz, U. Buetehorn, +6 authors W. Steinke
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in…
- 1 September 2005
The pharmacokinetics of BAY 59-7939 – a novel, oral, direct Factor Xa inhibitor – were investigated in rats and dogs in support of preclinical safety studies and clinical development. BAY 59-7939 was… Expand
Pharmacokinetics of the 8-methoxyquinolone, moxifloxacin: tissue distribution in male rats.
- H. M. Siefert, C. Kohlsdorfer, W. Steinke, A. Witt
- Biology, Medicine
- The Journal of antimicrobial chemotherapy
- 1 May 1999
BAY 12-8039 (moxifloxacin-HCl) and 14C-labelled BAY 12-8039 were administered to male rats as single i.v. and oral doses of 4.6 and 5.0 mg/kg bodyweight respectively. The distribution of… Expand
Quantitative distribution studies in animals: cross-validation of radioluminography versus liquid-scintillation measurement.
- W. Steinke, Y. Archimbaud, +4 authors J. Maas
- Chemistry, Medicine
- Regulatory toxicology and pharmacology : RTP
- 1 April 2000
The results of a cross-validation of the radioluminography (RLG) and liquid scintillation counting (LSC) methods are presented. The methods for the determination of radioactivity concentrations were… Expand