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Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy
Voltage-gated sodium channels (NaV) are critical for initiation of action potentials. Heterozygous loss-of-function mutations in NaV1.1 channels cause severe myoclonic epilepsy in infancy (SMEI).Expand
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Slow conductances in neurons from cat sensorimotor cortex in vitro and their role in slow excitability changes.
1. The electrophysiological and pharmacological properties of slow afterpotentials in large layer V neurons from cat sensorimotor cortex were studied in an in vitro slice preparation usingExpand
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Multiple potassium conductances and their functions in neurons from cat sensorimotor cortex in vitro.
1. Potassium conductances were studied in large layer V neurons using an in vitro slice preparation of cat sensorimotor cortex. The kinetics and pharmacological sensitivity of K+ currents wereExpand
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In vitro analysis of optimal stimuli for phase-locking and time-delayed modulation of firing in avian nucleus laminaris neurons
Neurons of the avian nucleus laminaris (NL) provide a neural substrate for azimuthal sound localization. We examined the optimal stimuli for NL neurons to maintain high discharge rates, reliableExpand
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Diversity of Gain Modulation by Noise in Neocortical Neurons: Regulation by the Slow Afterhyperpolarization Conductance
Neuronal firing is known to depend on the variance of synaptic input as well as the mean input current. Several studies suggest that input variance, or “noise,” has a divisive effect, reducing theExpand
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Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neurones
Non‐Technical Summary  Spiking neurones generate action potentials when the transmembrane voltage difference near the spike generating zone reaches a threshold level. Above the threshold, the inwardExpand
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Long-lasting reduction of excitability by a sodium-dependent potassium current in cat neocortical neurons.
1. The function and ionic mechanism of a slow outward current were studied in large layer V neurons of cat sensorimotor cortex using an in vitro slice preparation and single microelectrode voltageExpand
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Fractional differentiation by neocortical pyramidal neurons
Neural systems adapt to changes in stimulus statistics. However, it is not known how stimuli with complex temporal dynamics drive the dynamics of adaptation and the resulting firing rate. For singleExpand
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Membrane properties underlying the firing of neurons in the avian cochlear nucleus
Neurons of the avian nucleus magnocellularis (NM) relay auditory information from the VIIIth nerve to other parts of the auditory system. To examine the cellular properties that permit NM neurons toExpand
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