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Self-assembly of DNA into nanoscale three-dimensional shapes
Molecular self-assembly offers a ‘bottom-up’ route to fabrication with subnanometre precision of complex structures from simple components. DNA has proved to be a versatile building block forExpand
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Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching
Mitochondrial uncoupling protein 2 (UCP2) is an integral membrane protein in the mitochondrial anion carrier protein family, the members of which facilitate the transport of small molecules acrossExpand
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Rapid prototyping of 3D DNA-origami shapes with caDNAno
DNA nanotechnology exploits the programmable specificity afforded by base-pairing to produce self-assembling macromolecular objects of custom shape. For building megadalton-scale DNA nanostructures,Expand
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Folding DNA into Twisted and Curved Nanoscale Shapes
Stressful Self-Assembly One way to control shape during the assembly of an object is to design in stresses that cause a planned amount of deformation. Dietz et al. (p. 725; see the Perspective by LiuExpand
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Tug-of-War in Motor Protein Ensembles Revealed with a Programmable DNA Origami Scaffold
Push Me, Release, Pull You In eukaryotic cells, nearly all long-distance transport of cargos is carried out by the microtubule-based motors kinesin and dynein. These opposite-polarity motors moveExpand
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Dynein achieves processive motion using both stochastic and coordinated stepping
Processivity, the ability of single molecules to move continuously along a track, is a fundamental requirement of cargo-transporting molecular motors. Here, we investigate how cytoplasmic dynein, aExpand
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A 1.7-kilobase single-stranded DNA that folds into a nanoscale octahedron
Molecular self-assembly offers a means of spontaneously forming complex and well-defined structures from simple components. The specific bonding between DNA base pairs has been used in this way toExpand
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Challenges and opportunities for structural DNA nanotechnology.
We examine the technical challenges in the field of structural DNA nanotechnology and outline some of the promising applications that could be developed if these hurdles can be overcome. Expand
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Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes
Fluorescence in situ hybridization (FISH) is a powerful single-cell technique for studying nuclear structure and organization. Here we report two advances in FISH-based imaging. We first describe theExpand
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Three-Dimensional Structures Self-Assembled from DNA Bricks
Building with DNA One route for assembling three-dimensional (3D) DNA nanostructures is to start with a long natural DNA single strand and attach short strands, or “staples,” that cause the entireExpand
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