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Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription
TLDR
Data indicate that Pol II-associated Set2 methylates H3 providing a transcriptional memory which signals for deacetylation of ORFs by Rpd3S, which erases transcription elongation-associated acetylation to suppress intragenic transcription initiation. Expand
Histone Deacetylases Specifically Down-regulate p53-dependent Gene Activation*
TLDR
It is shown that mammalian histone deacetylase (HDAC)-1, -2, and -3 are all capable of down-regulating p53 function and are likely to be part of the mechanisms that control the physiological activity of p53. Expand
Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex.
TLDR
Dep1 and Sds3, unique components of Rpd3L, were required for RPD3L integrity and HDAC activity, and deletion of DEP1 enhanced telomeric silencing and derepressed INO1. Expand
Sas4 and Sas5 Are Required for the Histone Acetyltransferase Activity of Sas2 in the SAS Complex*
TLDR
It is shown that recombinant Sas2 has HAT activity that absolutely requires Sas4 and is stimulated by Sas5 and the possibility that the SAS HAT complex may acetylate free histones prior to their deposition onto DNA by Asf1 or CAF-I. Expand
SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae.
TLDR
The yeast SAS (Something About Silencing) complex and the histone variant H2A.Z synergistically prevent the ectopic propagation of heterochromatin and suggest a novel antisilencing mechanism near telomeres. Expand
Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development.
TLDR
The results indicate that FGF10 plays a pivotal role in maintaining epithelial progenitor cell proliferation as well as coordinating alveolar smooth muscle cell formation and vascular development. Expand
PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential.
TLDR
The discovery of a novel AE9a binding partner PRMT1 (protein arginine methyltransferase 1) is reported, suggesting a potential role ofPRMT1 in regulating leukemia development. Expand
Histone H4 lysine 16 acetylation breaks the genome's silence
TLDR
A recent biochemical study pinpoints this particular acetylation mark as a switch for changing chromatin from a repressive to a transcriptionally active state. Expand
RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cells.
TLDR
It is suggested that expression of endogenous RUNX1a facilitates the process of producing therapeutic HPCs from hPSCs, including both human embryonic stem cells and inducible pluripotent stem cells. Expand
Characterization of the Yeast Trimeric-SAS Acetyltransferase Complex*
TLDR
It is shown that the native yeast SAS complex is a small trimeric protein complex composed solely of Sas2, Sas4, and Sas5 with a molecular mass of about 125 kDa, and that the putative acetyl CoA binding motif in Sas2 is essential for both the in vivo silencing function and the enzymatic activity of SAS complex. Expand
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