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Recognition determinants of broadly neutralizing human antibodies against dengue viruses
X-ray structures of four broadly neutralizing antibodies in complex with the envelope glycoprotein E from dengue virus serotype 2 are described, revealing that the recognition determinants are at a serotype-invariant site at the E-dimer interface, including the exposed main chain of the E fusion loop and the two conserved glycan chains.
Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation
The overall fold and the active site architecture of the protein are remarkably similar to those of glycogen phosphorylase, indicating a common catalytic mechanism and comparable substrate‐binding properties and the structures provide useful hints to shed light on the allosteric regulation mechanisms of yeast/mammalian glycogen synthases.
The structure of a Staphylococcus aureus leucocidin component (LukF-PV) reveals the fold of the water-soluble species of a family of transmembrane pore-forming toxins.
The structure analysis and a multiple sequence alignment of all toxic components, suggest that LukF-PV represents the fold of any water-soluble secreted protein in this family of transmembrane pore-forming toxins.
Structure and Mechanism of the Alkyl Hydroperoxidase AhpC, a Key Element of the Mycobacterium tuberculosis Defense System against Oxidative Stress*
Structural and mutagenesis evidence points to a model for the electron transfer pathway in Mt AhpC that accounts for the unusual involvement of three cysteine residues in catalysis and suggests a mechanism by which MtAhpC can specifically interact with different redox partners.
The Crystal Structure of the Glutathione S-Transferase-like Domain of Elongation Factor 1Bγ from Saccharomyces cerevisiae*
The crystal structure of the N-terminal 219 residues (domain 1) of the conserved eukaryotic translation elongation factor 1Bγ (eEF1Bγ), encoded by the TEF3 gene in Saccharomyces cerevisiae, has been
Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme.
The biochemical characterization and the atomic resolution structures of a soluble PPM phosphatase from the saprophyte Mycobacterium smegmatis in complex with different ligands provide putative snapshots along the catalytic cycle, which support an associative reaction mechanism that differs in some important aspects from the currently accepted model and reinforces the hypothesis of convergent evolution in PPs.
Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway
The X‐ray crystal structure of human N‐acetyl serotonin methyltransferase (ASMT), the last enzyme of the melatonin biosynthesis pathway, is presented and mapping of the variants on to the 3‐dimensional structure clarifies why some are harmful and provides a structural basis for understanding melatonin deficiency in humans.
Crystal structure of the S15–rRNA complex
The 2.8 Å resolution crystal structure of the highly conserved S15–rRNA complex gives insights into the dual role of S15 in ribosome assembly and translational regulation.
Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase.
The crystal structure of the proline racemase from the human parasite Trypanosoma cruzi, a secreted enzyme that triggers host B cell polyclonal activation, is reported, suggesting that the mitogenic properties of TcPRACA depend on the exposure of transient epitopes in the ligand-free enzyme.
New Insights on DNA Recognition by ets Proteins from the Crystal Structure of the PU.1 ETS Domain-DNA Complex*
Correlation of this model with mutational analyses and chemical shift data on other ets proteins confirms this complex as a paradigm for ets DNA recognition.