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Copper-catalyzed intermolecular asymmetric propargylic dearomatization of indoles.
The first copper-catalyzed intermolecular dearomatization of indoles by an asymmetric propargylic substitution reaction was developed. This method provides a highly efficient synthesis of versatile
Iridium-Catalyzed Intramolecular Asymmetric Allylic Dearomatization Reaction of Pyridines, Pyrazines, Quinolines, and Isoquinolines.
The first Ir-catalyzed intramolecular asymmetric allylic dearomatization reaction of pyridines, pyrazines, quinolines, and isoquinolines has been developed and the results suggest the feasibility of an alternative process which features the formation of a quinolinium as the key intermediate.
Highly Diastereo- and Enantioselective Synthesis of Tetrahydro-5H-Indolo[2,3-b]quinolines through Copper-Catalyzed Propargylic Dearomatization of Indoles.
The first copper-catalyzed intermolecular asymmetric propargylic dearomatization/annulation cascade sequence of indoles via a copper-allenylidene amphiphilic intermediate has been achieved. This
Highly Diastereoselective Synthesis of Polycyclic Indolines through Formal [4+2] Propargylic Cycloaddition of Indoles with Ethynyl Benzoxazinanones.
This protocol provides a concise synthesis of tetrahydro-5 H -indolo[2,3- b ]quinolines and tetrahYDro-3 H -pyrrolo[3,2- b]quinoline, the core structures of alkaloid frameworks, featuring excellent yields, high diastereoselectivity, mild conditions and wide substrate scope.
Ni-Catalyzed Enantioselective Intermolecular Hydroamination of Branched 1,3-Dienes Using Primary Aliphatic Amines.
A Ni-catalyzed intermolecular enantioselective hydroamination of branched 1,3-dienes is reported, which provides direct access to valuable chiral allylic amines starting from linear or α-branched aliphatic primary amines or secondary amines.
Efficient Synthesis of N-Alkylated 4-Pyridones by Copper-Catalyzed Intermolecular Asymmetric Propargylic Amination.
Copper-catalyzed intermolecular asymmetric propargylic amination with 4-hydroxypyridines has been realized for the first time and can be easily transformed to the core structure of quinolizidine alkaloids.
Ni-Catalyzed Regiodivergent and Stereoselective Hydroalkylation of Acyclic Branched Dienes with Unstabilized C(sp3) Nucleophiles.
Using a chiral ligand and imides as carbon nucleophiles, a 3,4-addition protocol was developed enabling to construct two contiguous tertiary stereocenters in a single step with moderate to high levels of diastereocontrol and excellent enantiocontroll.
Radical addition of ketones and cyanide to olefinsviaacid catalyzed formation of intermediate alkenyl peroxides
γ-Cyanoketones are formed by double radical addition from olefins, ketones and sulfonyl cyanidesviareactive alkenyl peroxide intermediates.
Stereochemical studies in the trisnorlupane series
γ-Lupene (VI) has been converted into four alcohols (IX-XII) epimeric at C3 and C5 whose configuration has been established.