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Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis
Protein homology studies identified five kinases potentially capable of phosphorylating the Spo0F response regulator and initiating sporulation in Bacillus subtilis. Two of these kinases, KinA andExpand
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Autonomous pedestrians
TLDR
We address the challenging problem of emulating the rich complexity of real pedestrians in urban environments. Expand
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Small Molecule Antagonizes Autoinhibition and Activates AMP-activated Protein Kinase in Cells*
AMP-activated protein kinase (AMPK) serves as an energy sensor and is considered a promising drug target for treatment of type II diabetes and obesity. A previous report has shown that mammalian AMPKExpand
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The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time
Significance Identifying the source and dynamics of persistent HIV-1 during combinational antiretroviral therapy (cART) is crucial for understanding the barriers to curing HIV infection. ThroughExpand
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Autonomous pedestrians
TLDR
We address the difficult open problem of emulating the rich complexity of real pedestrians in urban environments. Expand
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The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock*♦
Caspase-1 is an essential effector of inflammation, pyroptosis, and septic shock. Few caspase-1 substrates have been identified to date, and these substrates do not account for its wide range ofExpand
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A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3
In a preliminary genome scan of 47 bipolar disorder families, we detected in one family a lod score of 3.41 at the PFKL locus on chromosome 21q22.3. The lod score is robust to marker alleleExpand
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Majority of CD4+ T cells from peripheral blood of HIV-1–infected individuals contain only one HIV DNA molecule
Neither the number of HIV-1 proviruses within individual infected cells in HIV-1–infected patients nor their genetic relatedness within individual infected cells and between cells and plasma virusExpand
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Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA.
BACKGROUND We address the key emerging question of whether Lin(-)/CD34(+) hematopoietic precursor cells (HPCs) represent an important latent reservoir of human immunodeficiency virus type 1 (HIV-1)Expand
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Spray-freeze-dried dry powder inhalation of insulin-loaded liposomes for enhanced pulmonary delivery.
Nowadays, growing attention has been paid to the pulmonary region as a target for the delivery of peptide and protein drugs, especially macromolecules with systemic effect like insulin, since theExpand
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