• Publications
  • Influence
LRRK2 regulates synaptic vesicle endocytosis.
The leucine-rich repeat kinase 2 (LRRK2) has been identified as the defective gene at the PARK8 locus causing the autosomal dominant form of Parkinson's disease (PD). Although several LRRK2 mutationsExpand
  • 310
  • 29
Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia
LRRK2, a Parkinson's disease associated gene, is highly expressed in microglia in addition to neurons; however, its function in microglia has not been evaluated. Using Lrrk2 knockdown (Lrrk2-KD)Expand
  • 142
  • 10
  • PDF
LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity.
LRRK2 is an autosomal dominant gene whose mutations cause familial Parkinson's disease (PD). The LRRK2 protein contains a functional kinase and a GTPase domain. PD phenotypes caused by LRRK2Expand
  • 87
  • 7
Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease.
  • W. Seol
  • Medicine, Biology
  • BMB reports
  • 1 April 2010
Parkinson's disease (PD) is the second most common neurodegenerative disease, and 5-10% of the PD cases are genetically inherited as familial PD (FPD). LRRK2 (leucine-rich repeat kinase 2) was firstExpand
  • 43
  • 4
Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor
Dopamine and the sex hormone testosterone are important factors regulating male sexual behavior. To investigate the possibility that these two factors are functionally interrelated, we investigatedExpand
  • 51
  • 3
Differential effects of antidepressant drugs on mTOR signalling in rat hippocampal neurons.
Recent studies suggest that ketamine produces antidepressant actions via stimulation of mammalian target of rapamycin (mTOR), leading to increased levels of synaptic proteins in the prefrontalExpand
  • 57
  • 3
  • PDF
Increased DJ-1 in Urine Exosome of Korean Males with Parkinson's Disease
Parkinson's disease (PD) is a difficult disease to diagnose although it is the second most common neurodegenerative disease. Recent studies show that exosome isolated from urine contains LRRK2 orExpand
  • 46
  • 2
  • PDF
Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5
Neurite outgrowth and its maintenance are essential aspects of neuronal cells for their connectivity and communication with other neurons. Recent studies showed that over-expression of eitherExpand
  • 51
  • 2
  • PDF
Effects of mood‐stabilizing drugs on dendritic outgrowth and synaptic protein levels in primary hippocampal neurons
Mood‐stabilizing drugs, such as lithium (Li) and valproate (VPA), are widely used for the treatment of bipolar disorder, a disease marked by recurrent episodes of mania and depression. GrowingExpand
  • 23
  • 2
  • PDF
LRRK2 impairs autophagy by mediating phosphorylation of leucyl‐tRNA synthetase
  • D. Ho, H. Kim, +5 authors W. Seol
  • Medicine, Biology
  • Cell biochemistry and function
  • 1 December 2018
Leucine‐rich repeat kinase 2 (LRRK2) is a causal gene of Parkinson disease. G2019S pathogenic mutation increases its kinase activity. LRRK2 regulates various phenotypes including autophagy, neuriteExpand
  • 18
  • 2