Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography‐mass spectrometry
- R. Dubbels, R. Reiter, W. Schloot
- BiologyJournal of Pineal Research
- 1 January 1995
These findings suggest that the consumption of plant materials that contain high levels of melatonin could alter blood melatonin levels of the indole as well as provide protection of macromolecules against oxidative damage.
A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes
- E. Schnakenberg, K. Fabig, W. Schloot
- BiologyEnvironmental Health
- 10 February 2007
The results from the study population show that individuals being slow acetylators and/or harbouring a homozygous GSTM1 and/ or GSTT1 deletion reported chemical-related hypersensitivity more frequently.
Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer
- E. Schnakenberg, R. Breuer, R. Werdin, K. Dreikorn, W. Schloot
- BiologyCytogenetic and Genome Research
- 30 January 2001
It is reported that the mutation of intron 6 of GSTM3 increases the risk for bladder cancer and the assumption that the lack of detoxification by glutathione conjugation predispose to bladder cancer when at least one of two alleles is affected.
Regional fine mapping of the multiple‐aberration region involved in uterine leiomyoma, lipoma, and pleomorphic adenoma of the salivary gland to 12q15
- S. Wanschura, B. Kazmierczak, W. Schloot
- Medicine, BiologyGenes, Chromosomes and Cancer
- 1 September 1995
It is concluded that, despite the cytogenetic breakpoint assignment to the three bands 12q13‐15 in individual uterine leiomyomas, lipomas, and pleomorphic adenomas of the salivary glands in the past, most likely 12q15 is the only 12q breakpoint site in these three distinct solid tumor types.
Gender‐specific effects of NAT2 and GSTM1 in bladder cancer
- E. Schnakenberg, M. Lustig, W. Schloot
- BiologyClinical Genetics
- 1 April 2000
In male patients, slow acetylators were identified as carrying a significant increased risk of developing bladder cancer, in particular when the genotype NAT2*5B/*6A was combined with the GSTM1 null genotype, and the same genotype combination significantly protected female patients from bladder cancer.
No rearrangement of c-mos in salivary gland pleomorphic adenomas with 8q12 aberrations.
- B. Rommel, J. Bullerdiek, S. Bartnitzke, W. Schloot
- MedicineCancer Genetics and Cytogenetics
- 15 October 1990
Genotyping of the polymorphic N‐acetyltransferase (NAT2) and loss of heterozygosity in bladder cancer patients
- E. Schnakenberg, C. Ehlers, W. Schloot
- Biology, MedicineClinical Genetics
- 1 May 1998
The distribution of allelic constellations of the N‐acetyltransferase (NAT2) by genotyping patients with bladder cancer was studied to identify slow acetylators and divide bladder cancer patients in males and females the genotype NAT2 * 5B/NAT2 * 6A occured with much higher frequencies.
[Genetic differences in enzymes of folic acid metabolism in patients with lip-jaw-palate clefts and their relatives].
- R. Grunert, A. Braune, E. Schnackenberg, W. Schloot, H. Krause
- Medicine, BiologyMund-, Kiefer- und Gesichtschirurgie
- 1 May 2002
The results provide no evidence that the above MTHFR gene mutations are a risk factor for CLP, and a NAT1 gene mutation instead could be a risk factors forCLP.
Structural rearrangements of chromosome Nr 8 involving 8q12—a primary event in pleomorphic ademona of the parotid gland
- J. Bullerdiek, G. Raabe, S. Bartnitzke, C. Böschen, W. Schloot
- MedicineGenetica
- 15 June 1987
Nine pleomorphic adenomas of the human parotid gland were investigated and the hypothesis is proposed that in these cases the chromosomal rearrangement is the primary event in tumorigenesis, leading to activation of a so far unknown oncogene located most likely at 8q12.
Rearrangements of chromosome region 12q13----q15 in pleomorphic adenomas of the human salivary gland (PSA).
- J. Bullerdiek, S. Bartnitzke, M. Weinberg, R. Chilla, J. Haubrich, W. Schloot
- MedicineCytogenetics and Cell Genetics
- 1987
Nine of 40 pleomorphic salivary gland adenomas showed clonal aberrations of chromosome 12, with a breakpoint at 12q13----q15, which suggests that this type of aberration is a primary change directly involved in the genesis of PSA.
...
...