• Publications
  • Influence
Neuroendocrine control of thymus physiology.
The thymus gland is a central lymphoid organ in which bone marrow-derived T cell precursors undergo differentiation, eventually leading to migration of positively selected thymocytes to theExpand
  • 273
  • 11
The Thymus Is a Common Target Organ in Infectious Diseases
  • W. Savino
  • Medicine, Biology
  • PLoS pathogens
  • 1 June 2006
Infectious disease immunology has largely focused on the effector immune response, changes in the blood and peripheral lymphoid organs of infected individuals, and vaccine development. Studies of theExpand
  • 216
  • 8
  • PDF
Control of human thymocyte migration by Neuropilin-1/Semaphorin-3A-mediated interactions
It is largely established that molecules first discovered in the nervous system are also found in the immune system. Neuropilin-1 (NP-1) was initially identified to mediate semaphorin-inducedExpand
  • 98
  • 7
  • PDF
APRIL promotes B-1 cell-associated neoplasm.
A tumor-supporting role for the TNF-like ligand APRIL has been suggested. Here we describe that 9- to 12-month-old APRIL transgenic mice develop lymphoid tumors that originate from expansion of theExpand
  • 169
  • 6
A Schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine.
Molecular cloning of components of protective antigenic preparations has suggested that related parasite fatty acid-binding proteins could form the basis of the protective immune crossreactivityExpand
  • 190
  • 5
Anti-CD4 abrogates rejection and reestablishes long-term tolerance to syngeneic newborn hearts grafted in mice chronically infected with Trypanosoma cruzi
The contribution of autoimmunity in the genesis of chronic Chagas' heart pathology is not clear. In the present study, we show that: (a) BALB/c mice chronically infected with Trypanosoma cruzi rejectExpand
  • 155
  • 4
  • PDF
The thymus is a common target in malnutrition and infection.
Malnutrition, secondary to deficiency in intake of proteins, minerals or vitamins, consistently results in changes in the thymus. This organ undergoes a severe atrophy due to apoptosis-inducedExpand
  • 109
  • 4
  • PDF
Functional Insulin-Like Growth Factor-1/Insulin-Like Growth Factor-1 Receptor-Mediated Circuit in Human and Murine Thymic Epithelial Cells
Interactions between thymocytes and thymic epithelial cell (TEC) can be modulated by growth hormone via insulin-like growth factor-1 (IGF-1). In this study, we showed IGF-1 and IGF-1 receptor mRNAExpand
  • 44
  • 4
Inhibitory effect of semaphorin‐3A, a known axon guidance molecule, in the human thymocyte migration induced by CXCL12
Intrathymic T cell differentiation takes place within the thymic lobules and depends on interactions between developing thymocytes and cells of the thymic microenvironment. Along withExpand
  • 27
  • 4
Expression of prolactin receptors in murine lymphoid cells in normal and autoimmune situations.
We have analyzed the expression of prolactin receptors (PRL-R) on murine lymphoid cells by using flow cytofluorometry analysis with biotinylated anti-PRL-R mAb raised against several epitopes of theExpand
  • 138
  • 3