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The dynamic genome of Hydra
TLDR
Comparisons of the Hydra genome to the genomes of other animals shed light on the evolution of epithelia, contractile tissues, developmentally regulated transcription factors, the Spemann–Mangold organizer, pluripotency genes and the neuromuscular junction. Expand
Immunogold-labeled S-phase neoblasts, total neoblast number, their distribution, and evidence for arrested neoblasts in Macrostomum lignano (Platyhelminthes, Rhabditophora)
TLDR
In Macrostomum lignano, the incorporation of 5′-bromo-2′-deoxyuridine in neoblasts confirmed the distribution of S-phase cells in two lateral bands, and double labeling of mitoses and FMRF-amide revealed a close spatial relationship of mesodermal neblasts with the nervous system. Expand
Antifungal Protein PAF Severely Affects the Integrity of the Plasma Membrane of Aspergillus nidulans and Induces an Apoptosis-Like Phenotype
TLDR
Detailed insights are offered into the mechanism of action of PAF and evidence for the induction of a programmed cell death-like phenotype is given and the hyperpolarization of the plasma membrane in PAF-treated Aspergillus nidulans hyphae is proved. Expand
Stem cells are differentially regulated during development, regeneration and homeostasis in flatworms.
TLDR
The isolation and characterization of the piwi homologue macpiwi in the flatworm Macrostomum lignano is described, which addresses new questions in flatworm stem cell research and provides a basis for comparison with higher organisms. Expand
Development of the musculature in the limpet Patella (Mollusca, Patellogastropoda)
TLDR
Because the adult shell muscles are entirely independent from the various larval muscular systems, several current hypotheses on the ontogeny and phylogeny of the early gastropod muscle system have to be reconsidered. Expand
Production and characterisation of cell- and tissue-specific monoclonal antibodies for the flatworm Macrostomum sp.
TLDR
Considering the current lack of specific markers the obtained mABs will be particularly helpful studying embryonic and postembryonic development, pattern formation, cell differentiation, regeneration and reproductive allocation in Macrostomum sp. Expand
The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling
TLDR
Data indicate that the ECD, previously thought to be dispensable for vertebrate Smo function, both regulates Smo ciliary localization and is essential for high-level Hh signaling. Expand
Inhibition of malarial topoisomerase II in Plasmodium falciparum by antisense nanoparticles.
TLDR
This is the first study demonstrating the susceptibility of P. falciparum to antisense nanoparticles and nanoparticles were much more sequence specific in their antisense effect than free ODNs. Expand
Characterization of the stem cell system of the acoel Isodiametra pulchra
TLDR
The acoel Isodiametra pulchra is introduced as a potential new model organism, suitable to address developmental questions in this understudied phylum, and it is shown that neoblasts in I. pulchRA are crucial for tissue homeostasis, development and regeneration. Expand
The impact of TiO2 nanoparticles on uptake and toxicity of benzo(a)pyrene in the blue mussel (Mytilus edulis).
TLDR
The results suggest that TiO2NP can act as additional stressor, or potentially alters B(a)P toxicity by activation, as well as antioxidant enzyme superoxide dismutase, catalase and glutathione peroxidase were impacted by the various exposure regimes, indicating oxidative stress in the contaminant exposure groups. Expand
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