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Synthetic DNA delivery systems
The ability to safely and efficiently transfer foreign DNA into cells is a fundamental goal in biotechnology. Toward this end, rapid advances have recently been made in our understanding of… Expand
Tissue-engineered vascular grafts transform into mature blood vessels via an inflammation-mediated process of vascular remodeling
- J. Roh, R. Sawh-Martinez, +14 authors C. Breuer
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 9 March 2010
Findings suggest TEVGs transform into functional neovessels via an inflammatory process of vascular remodeling in mice implanted with human BMC-seeded scaffolds. Expand
Antibody diffusion in human cervical mucus.
It is predicted that particles as large as viruses can diffuse rapidly through human midcycle cervical mucus, provided the particle forms no adhesive interactions with mucus glycoproteins. Expand
Enhanced and prolonged cross‐presentation following endosomal escape of exogenous antigens encapsulated in biodegradable nanoparticles
N nanoparticles from a biodegradable polymer, poly(d,l‐lactide‐co‐glycolide) (PLGA), are generated to deliver antigen into the major histocompatibility complex (MHC) class I antigen presentation pathway and show the unique properties of PLGA particle‐mediated antigen delivery, potentially facilitating the clinical use of these particles in vaccination. Expand
Drug Delivery: Engineering Principles for Drug Therapy
- W. Saltzman
- 15 March 2001
Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry… Expand
Pharmacokinetics of interstitial delivery of carmustine, 4-hydroperoxycyclophosphamide, and paclitaxel from a biodegradable polymer implant in the monkey brain.
Pharmacokinetic analysis indicated that tissue exposure to carmustine area under concentration-time curve achieved by polymeric delivery was 4-1200 times higher than that produced by i.v. administration of a higher dose. Expand
PEGylated PLGA nanoparticles for the improved delivery of doxorubicin.
- Jason Park, P. Fong, +4 authors T. Fahmy
- Materials Science, Medicine
- Nanomedicine : nanotechnology, biology, and…
- 1 December 2009
UNLABELLED We hypothesize that the efficacy of doxorubicin (DOX) can be maximized and dose-limiting cardiotoxicity minimized by controlled release from PEGylated nanoparticles. To test this… Expand
Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA
- K. Woodrow, Y. Cu, C. Booth, J. Saucier-Sawyer, M. J. Wood, W. Saltzman
- Chemistry, Medicine
- Nature materials
- 9 April 2009
This is the first report demonstrating that biodegradable polymer nanoparticles are effective delivery vehicles for siRNA in the vaginal mucosa, using nanoparticles composed entirely of FDA-approved materials. Expand
The uptake and intracellular fate of PLGA nanoparticles in epithelial cells.
- Malgorzata S Cartiera, Katherine M. Johnson, V. Rajendran, M. Caplan, W. Saltzman
- Biology, Medicine
- 1 May 2009
A model for the intracellular fate of particles that is consistent with the experimental data is presented and demonstrated that NPs are capable of entering cells of all three types of epithelium. Expand
Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model.
The ability to create sub-1mm ID biodegradable tubular scaffolds that are functional as vascular grafts are presented, and an experimental approach for the study of vascular tissue engineering using mouse models is provided. Expand