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Principles of Nucleic Acid Structure
TLDR
The goal of this series is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields.
Three-dimensional structure of cyanobacterial photosystem I at 2.5 Å resolution
TLDR
The structure of photosystem I from the thermophilic cyanobacterium Synechococcus elongatus described here provides a picture at atomic detail of 12 protein subunits and 127 cofactors comprising 96 chlorophylls, 2 phylloquinones, 3 Fe4S4 clusters, 22 carotenoids, 4 lipids, a putative Ca2+ ion and 201 water molecules.
Towards complete cofactor arrangement in the 3.0 Å resolution structure of photosystem II
TLDR
The most complete cyanobacterial photosystem II structure obtained so far is described, showing locations of and interactions between 20 protein subunits and 77 cofactors per monomer, and provides information about the Mn4Ca cluster, where oxidation of water takes place.
Crystal structure of photosystem II from Synechococcus elongatus at 3.8 Å resolution
TLDR
The X-ray structure of photosystem II is described on the basis of crystals fully active in water oxidation, shows how protein subunits and cofactors are spatially organized and the larger subunits are assigned and the locations and orientations of the cofacters are defined.
Cyanobacterial photosystem II at 2.9-Å resolution and the role of quinones, lipids, channels and chloride
TLDR
Putative oxygen positions obtained from a Xenon derivative indicate a role for lipids in oxygen diffusion to the cytoplasmic side of PSII, and the chloride position suggests a role in proton-transfer reactions.
Structural basis of gene regulation by the tetracycline inducible Tet repressor–operator system
TLDR
The crystal structure of the TetR homodimer in complex with its palindromic DNA operator at 2.5 Å resolution is presented and the mechanism of induction to be deduced, which abolishing the affinity of TetR for its operator DNA.
Role of the Clathrin Terminal Domain in Regulating Coated Pit Dynamics Revealed by Small Molecule Inhibition
Lisa von Kleist, Wiebke Stahlschmidt, Haydar Bulut, Kira Gromova, Dmytro Puchkov, Mark J. Robertson, Kylie A.MacGregor, Nikolay Tomilin, Arndt Pechstein, Ngoc Chau, Megan Chircop, Jennette Sakoff,
Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance.
TLDR
The 2.5 angstrom resolution crystal structure of the homodimeric Tet repressor complexed with tetracycline-magnesium reveals detailed drug recognition and the orientation of the operator-binding helix-turn-helix motifs of the repressor is inverted in comparison with other DNA binding proteins.
Streptococcus pyogenes pSM19035 requires dynamic assembly of ATP-bound ParA and ParB on parS DNA during plasmid segregation
TLDR
It is indicated that the molar ω2 : δ2 ratio regulates the polymerization properties of (δ•ATP•Mg2+)2 on and depolymerization from parS DNA, thereby controlling the temporal and spatial segregation of pSM19035 before cell division.
The mycosubtilin synthetase of Bacillus subtilis ATCC6633: a multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase.
TLDR
The mycosubtilin synthetase reveals features unique for peptide synthetases as well as for fatty acid synthases, which are presented as a model for the biosynthesis of iturin lipopeptide antibiotics.
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