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Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption.
The P2X7 nucleotide receptor is an ATP-gated ion channel expressed widely in cells of hematopoietic origin. Our purpose was to explore the involvement of the P2X7 receptor in bone development andExpand
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Overview: animal models of osteopenia and osteoporosis.
  • W. S. Jee, W. Yao
  • Medicine
  • Journal of musculoskeletal & neuronal…
  • 1 March 2001
Prior to initiating a clinical trial in a post-menopausal osteoporosis study, it is reasonable to recommence the evaluation of treatment in the 9-month-old ovariectomized female rat. A female rat ofExpand
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  • Open Access
The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo.
Administration of cyclosporine A to male and female rats accelerates bone remodeling and causes bone loss, among other side-effects. The newer immunosuppressant drugs, FK506 and CsG, have beenExpand
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Effects of spaceflight on trabecular bone in rats.
Alterations in trabecular bone were observed in growing male Wistar rats after 18.5 days of orbital flight on the COSMOS 1129 biosatellite. Spaceflight induced a decreased mass of mineralized tissueExpand
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The Skeletal Tissues
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Prostaglandin E2 enhances cortical bone mass and activates intracortical bone remodeling in intact and ovariectomized female rats.
To assess the efficacy of prostaglandin E2 (PGE2) in augmenting cortical bone mass, graded doses of PGE2 were subcutaneously administered for 30 days to seven-month old sham-ovariectomized (SHAM) andExpand
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Parathyroid Hormone and Mechanical Usage Have a Synergistic Effect in Rat Tibial Diaphyseal Cortical Bone
  • Y. Ma, W. S. Jee, +5 authors C. Lin
  • Medicine, Biology
  • Journal of bone and mineral research : the…
  • 1 March 1999
Previous reports showed that bone mass and architecture only partially recovered by remobilization (RM) after immobilization (IM)‐induced osteopenia, and that parathyroid hormone (PTH) had anExpand
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New bone formation with teriparatide [human parathyroid hormone-(1-34)] is not retarded by long-term pretreatment with alendronate, estrogen, or raloxifene in ovariectomized rats.
With the ready availability of several osteoporosis therapies, teriparatide [human PTH-(1-34)] is likely to be prescribed to postmenopausal women with prior exposure to agents that prevent bone loss,Expand
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Adaptation of cancellous bone to aging and immobilization in the rat: A single photon absorptiometry and histomorphometry study
Nine‐month‐old female rats were double‐labled with bone markers and subjected to right hindlimb immobilization or served as control for 0, 2, 10, 18, or 26 weeks. The right limb was immobilizedExpand
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The role of bone cells in increasing metaphyseal hard tissue in rapidly growing rats treated with prostaglandin E2.
The skeletal effects of graded doses of prostaglandin E2 (PGE2) given to weanling Sprague-Dawley rats for 3 weeks were investigated to elucidate the role of bone cells in increasing hard tissue mass.Expand
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