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Radiosensitization, mutagenicity, and toxicity of Escherichia coli by several nitrofurans and nitroimidazoles.
TLDR
Representative nitrofurans and nitroimidazoles were found to sensitize hypoxic Escherichia coli cells to X irradiation, and mutagenic to E. coli, suggesting that potential radiosensitizers with fewer side effects could be screened using bacteria. Expand
Potential radiosensitizing agents. Dinitroimidazoles.
New compounds of the nitroimidazole series have been synthesized as radiosensitizers which selectively sensitize hypoxic cells to the lethal effect of radiation. The reaction ofExpand
Evaluation of 2-amino-5-nitrothiazole as a hypoxic cell radiosensitizer.
TLDR
Findings suggest that nitrothiazoles might be an interesting class of nitroheterocyclic radiosensitizers, but that molecules with increased solubility and improved pharmacokinetics would be necessary for efficacy in vivo. Expand
Radiosensitization, pharmacokinetics, and toxicity of a 2-nitroimidazole nucleoside (RA-263).
TLDR
The in vivo radiosensitization experiments conducted by the in vivo-in vitro cloning assay with the EMT6 mammary tumor indicate that RA-263 is an effective sensitizer and this agent was also significantly less mutagenic than misonidazole in a strain of Escherichia coli. Expand
Hypoxic radiosensitizers: prospects for effective compounds with fewer toxic side-effects.
TLDR
Of the compounds examined, KA121 (2,5-dinitroimidazole) is the most promising for future study because it combines good radiosensitization with low mutagenicity and toxicity. Expand
Two different metabolic fates of 5-ethyl-6-azauracil in mice.
TLDR
Findings indicate that 5-cthyl-6-azauracil is metabolized in an anabolic fashion similar to that of a natural component of nucleic acids, uracil, and is oxidized in a manner similar to the calabolism of barbiturates. Expand
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