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- Publications
- Influence
Synthetic Biology Moving into the Clinic
- W. Ruder, Ting Lu, J. Collins
- Biology, Medicine
- Science
- 2 September 2011
Synthetic biology is an emerging field focused on engineering biomolecular systems and cellular capabilities for a variety of applications. Substantial progress began a little over a decade ago with… Expand
Artificial cells: building bioinspired systems using small-scale biology.
Artificial cells have generated much interest since the concept was introduced by Aleksandr Oparin in the 1920s, and they have had an impact on the pharmaceutical and biotechnology industry in… Expand
Low-cost feedback-controlled syringe pressure pumps for microfluidics applications
TLDR
Probing Cellular Dynamics with a Chemical Signal Generator
- Brandon Kuczenski, W. Ruder, W. Messner, P. LeDuc
- Chemistry, Medicine
- PloS one
- 16 March 2009
Observations of material and cellular systems in response to time-varying chemical stimuli can aid the analysis of dynamic processes. We describe a microfluidic “chemical signal generator,” a… Expand
Programming Surface Chemistry with Engineered Cells.
- R. Zhang, K. Heyde, F. Y. Scott, Sung-Ho Paek, W. Ruder
- Chemistry, Medicine
- ACS synthetic biology
- 6 June 2016
We have developed synthetic gene networks that enable engineered cells to selectively program surface chemistry. E. coli were engineered to upregulate biotin synthase, and therefore biotin synthesis,… Expand
Creating biological nanomaterials using synthetic biology
- M. Rice, W. Ruder
- Materials Science, Medicine
- Science and technology of advanced materials
- 3 December 2013
Abstract Synthetic biology is a new discipline that combines science and engineering approaches to precisely control biological networks. These signaling networks are especially important in fields… Expand
Three-dimensional microfiber devices that mimic physiological environments to probe cell mechanics and signaling.
- W. Ruder, Erica D Pratt, +5 authors P. LeDuc
- Chemistry, Medicine
- Lab on a chip
- 24 April 2012
Many physiological systems are regulated by cells that alter their behavior in response to changes in their biochemical and mechanical environment. These cells experience this dynamic environment… Expand
Exploring Host-Microbiome Interactions using an in Silico Model of Biomimetic Robots and Engineered Living Cells
The microbiome’s underlying dynamics play an important role in regulating the behavior and health of its host. In order to explore the details of these interactions, we created an in silico model of… Expand
Sudden motility reversal indicates sensing of magnetic field gradients in Magnetospirillum magneticum AMB-1 strain
- L. M. González, W. Ruder, A. P. Mitchell, W. Messner, P. LeDuc
- Biology, Medicine
- The ISME Journal
- 1 June 2015
Many motile unicellular organisms have evolved specialized behaviors for detecting and responding to environmental cues such as chemical gradients (chemotaxis) and oxygen gradients (aerotaxis).… Expand
Controlling Magnetotactic Bacteria through an Integrated Nanofabricated Metallic Island and Optical Microscope Approach
- L. M. González, W. Ruder, P. LeDuc, W. Messner
- Materials Science, Medicine
- Scientific reports
- 20 February 2014
Herein, we demonstrate the control of magnetotactic bacteria through the application of magnetic field gradients with real-time visualization. We accomplish this control by integrating a pair of… Expand