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Adrenal steroid receptors and actions in the nervous system.
Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons
The constitutive neuronal CXCR4 expression suggests that SDF‐1/CXCL12 could be involved in neuronal communication and possibly linked up with cholinergic and dopaminergic neurotransmission and related disorders. Expand
Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist‐treated rats
It is demonstrated that MCP‐1/CCL2 can alter pain neurotransmission in healthy rats and is prevented by the selective CCR2 antagonist (INCB3344), indicating that preventing the activation of C CR2 might provide a fruitful strategy for treating pain. Expand
Cellular distribution of neurotensin receptors in rat brain: Immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor
The results suggest that the neurotensin high affinity receptor protein is associated with a neuronal population that is more extensive than originally surmised from in situ hybridization studies and confirms that some of its effects are exerted on projection neurons. Expand
Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain
The results provide the first evidence for constitutive CCR2 receptor expression with precise neuroanatomical and cellular localizations in the brain, and its regulation during an inflammatory process, suggesting that MCP‐1/CCL2 and C CR2 play important physiological and pathophysiological role(s) in the CNS. Expand
Current status of chemokines in the adult CNS
The role of these chemokines in cellular communication may make it possible to identify new pathways of neuron-neuron, glia- glia or neuron-glia communications relevant to both normal brain function and neuroinflammatory and neurodegenerative diseases; to develop new therapeutic approaches for currently untreatable brain diseases. Expand
Constitutive neuronal expression of CCR2 chemokine receptor and its colocalization with neurotransmitters in normal rat brain: Functional effect of MCP‐1/CCL2 on calcium mobilization in primary
The constitutive neuronal CCR2 expression in selective brain structures suggests that this receptor could be involved in neuronal communication and possibly associated with cholinergic and dopaminergic neurotransmission and related disorders. Expand
Chemokine Action in the Nervous System
Chemokines are a large group of proteins that play a central role in regulating the migration of leukocytes and play a key role in coordinating inflammatory and immune responses. Expand
Chemokines: a new class of neuromodulator?
These findings, together with the pharmacological development of agonists and antagonists that are selective for chemokine receptors and can cross the blood–brain barrier, open a new era of research in neuroscience. Expand
Highly regionalized distribution of stromal cell‐derived factor‐1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons
The first evidence that SDF‐1/CXCL12 is constitutively expressed in cholinergic neurons in the medial septum and substantia innominata and in dopaminergic neuron in substantia nigra pars compacta and the ventral tegmental area is provided. Expand