• Publications
  • Influence
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
TLDR
Efficacy data demonstrate that BMS-247550 has the potential to surpass Taxol in both clinical efficacy and ease of use (i.e., less frequent treatment schedule and/or oral administration).
How Did It Happen? *
  • W. Rose
  • History
    Annals of the New York Academy of Sciences
  • 1 May 1979
TLDR
From time to time, some of my friends have stated or implied that my interest in amino acids stemmed from the contacts I had with Thomas B. Osborne and Lafayette B. Mendel during the years I was a graduate student at Yale University.
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.
Two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol (1) and episilvestrol (2), were isolated from the fruits and twigs of Aglaia silvestris by bioassay-guided
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.
Two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol (1) and episilvestrol (2), were isolated from the fruits and twigs of Aglaia silvestris by bioassay-guided
Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.
TLDR
The FTI, BMS-214662, demonstrated broad spectrum activity against human tumors, but murine tumors were not as sensitive and the most potent apoptotic FTI known and demonstrated broad range yet robust cell-selective cytotoxic activity against a panel of cell lines with diverse histology.
Preclinical antitumor activity of two novel taxanes
TLDR
Two new taxane analogs were characterized as superior to paclitaxel or Taxotere in several in vivo tumor models and are currently in phase I or II clinical trials.
Correlation of pharmacokinetics with the antitumor activity of Cetuximab in nude mice bearing the GEO human colon carcinoma xenograft
  • F. Luo, Z. Yang, F. Lee
  • Medicine, Biology
    Cancer Chemotherapy and Pharmacology
  • 10 June 2005
TLDR
The pharmacokinetics of Cetuximab in nude mice at efficacious dose levels was characterized and the preclinical optimal dose and active plasma drug concentration with those determined in clinical studies were compared.
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