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Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
Biological analysis of the 18 proteins found in blood plasma points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease.
Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
- W. Robinson, Christin M. Lepus, J. Sokolove
- Medicine, BiologyNature Reviews Rheumatology
- 1 October 2016
Osteoarthritis has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis, and increasing insight into the inflammatory underpinnings of OA holds promise for the development of new, disease-modifying therapies.
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
In vivo administration of hirudin or recombinant activated protein C reduced disease severity in experimental autoimmune encephalomyelitis and suppressed Th1 and Th17 cytokines in astrocytes and immune cells.
Identification of a central role for complement in osteoarthritis
It is shown that complement, specifically, the membrane attack complex (MAC)-mediated arm of complement, is crucial to the development of arthritis in three different mouse models of osteoarthritis, and dysregulation of complement in synovial joints has a key role in the pathogenesis of arthritis.
Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite
Catabolites of Trp suppressed proliferation of myelin-specific T cells and inhibited production of proinflammatory T helper–1 (TH1) cytokines, and offer a new strategy for treating TH1-mediated autoimmune diseases such as MS.
Lipid microarrays identify key mediators of autoimmune brain inflammation
Recent studies suggest that increased T-cell and autoantibody reactivity to lipids may be present in the autoimmune demyelinating disease multiple sclerosis. To perform large-scale multiplex analysis…
Periodontitis and Porphyromonas gingivalis in Patients With Rheumatoid Arthritis
To examine the degree to which shared risk factors explain the relationship of periodontitis (PD) to rheumatoid arthritis (RA) and to determine the associations of PD and Porphyromonas gingivalis…
Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor.
It is demonstrated that cFb-IC can costimulate macrophages via dual engagement of TLR-4 and FcγR, resulting in the synergistic induction of TNF production, suggesting a potential role of citrullination in increasing the potency of an endogenous innate immune ligand.
Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis.
It is demonstrated that antibodies against citrullinated proteins are centrally involved in the pathogenesis of autoimmune arthritis.