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THE PHARMACOLOGY OF FLAXEDIL, WITH OBSERVATIONS ON CERTAIN ANALOGS
  • W. Riker, W. Wescoe
  • Chemistry, Medicine
    Annals of the New York Academy of Sciences
  • 1 October 1951
TLDR
The present report is concerned with the pharmacologic properties of Flaxedil, particularly as they compare with those of d-tubocurarine, which have had a considerable preliminary clinical trial in the practice of anesthesiology.
Succinylcholine: Mechanism of Fasciculations and Their Prevention by d‐Tubocurarine or Diphenylhydantoin
TLDR
It is concluded that the effectiveness of a pretreatment regimen for prevention of Sch fasciculations depends on a prejunctional suppression of repetitive firing generated by MNTs.
Destruction of Mammalian Motor Nerve Terminals by Black Widow Spider Venom
TLDR
Electron microscopy of the poisoned nerve-muscle junction shows a sequence of motor nerve ending damage that culminates in disruption of the prejunctional membrane and loss of all organelles, including synaptic vesicles, in the cat.
The motor nerve terminal as the primary focus for drug-in-duced facilitation of neuromuscular transmission.
TLDR
3-OH PTMA may overcome completely a profound curare paralysis, while a less severe block may be incompletely dissipated by 3-OH PTEA, highlighting the importance of the methonium center as an adjunct in anti-curare action.
THE PHARMACOLOGY OF ANTI‐CURARE AGENTS
  • W. Wescoe, W. Riker
  • Chemistry, Medicine
    Annals of the New York Academy of Sciences
  • 1 October 1951
TLDR
The working hypothesis was formulated that neostigmine probably possessed, in addition to its anti-cholinesterase properties, the property of acting directly on acetylcholine-sensitive receptors in skeletal muscle, and the potent anti-curare action of this compound suggested its use in clinical anesthesiology.
Myokymia and impaired muscular relaxation with continuous motor unit activity.
TLDR
The neurophysiological and pathological findings in these two cases of the syndrome of myokymia indicate an abnormality of peripheral nerve in this disorder.
Glucocorticoid effects on spinal cord function.
Pharmacology of motor nerve terminals.
The direct action of prostigmine on skeletal muscle; its relationship to the choline esters.
  • W. Riker, W. Wescoe
  • Chemistry, Medicine
    The Journal of pharmacology and experimental…
  • 1 September 1946
TLDR
It is concluded that the action of prostigmine is primarily a direct one and differs from that of a primary anti-esterase (DFP), and it is suggested that prostIGmine be classified pharmacologically with the choline esters.
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