THE PHARMACOLOGY OF FLAXEDIL, WITH OBSERVATIONS ON CERTAIN ANALOGS
The present report is concerned with the pharmacologic properties of Flaxedil, particularly as they compare with those of d-tubocurarine, which have had a considerable preliminary clinical trial in the practice of anesthesiology.
Succinylcholine: Mechanism of Fasciculations and Their Prevention by d‐Tubocurarine or Diphenylhydantoin
It is concluded that the effectiveness of a pretreatment regimen for prevention of Sch fasciculations depends on a prejunctional suppression of repetitive firing generated by MNTs.
Destruction of Mammalian Motor Nerve Terminals by Black Widow Spider Venom
Electron microscopy of the poisoned nerve-muscle junction shows a sequence of motor nerve ending damage that culminates in disruption of the prejunctional membrane and loss of all organelles, including synaptic vesicles, in the cat.
Pharmacology of motor nerve terminals.
The motor nerve terminal as the primary focus for drug-in-duced facilitation of neuromuscular transmission.
- W. Riker, J. Roberts, F. Standaert, H. Fujimori
- BiologyJournal of Pharmacology and Experimental…
- 1 November 1957
3-OH PTMA may overcome completely a profound curare paralysis, while a less severe block may be incompletely dissipated by 3-OH PTEA, highlighting the importance of the methonium center as an adjunct in anti-curare action.
THE PHARMACOLOGY OF ANTI‐CURARE AGENTS
The working hypothesis was formulated that neostigmine probably possessed, in addition to its anti-cholinesterase properties, the property of acting directly on acetylcholine-sensitive receptors in skeletal muscle, and the potent anti-curare action of this compound suggested its use in clinical anesthesiology.
Myokymia and impaired muscular relaxation with continuous motor unit activity.
The neurophysiological and pathological findings in these two cases of the syndrome of myokymia indicate an abnormality of peripheral nerve in this disorder.
Glucocorticoid effects on spinal cord function.
Exicitatory and anticurare properties of acetylcholine and related quaternary ammonium compounds at the neuromuscular junction.
- W. Riker
- BiologyPharmacological Reviews
- 1 March 1953
The direct action of prostigmine on skeletal muscle; its relationship to the choline esters.
It is concluded that the action of prostigmine is primarily a direct one and differs from that of a primary anti-esterase (DFP), and it is suggested that prostIGmine be classified pharmacologically with the choline esters.