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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
18 new loci associated with body mass index are identified, one of which includes a copy number variant near GPRC5B, and genes in other newly associated loci may provide new insights into human body weight regulation.
Validity of the Brief Patient Health Questionnaire Mood Scale (PHQ-9) in the general population.
A classification of chronic pain for ICD-11
Chronic pain has been recognized as pain that persists past normal healing time5 and hence lacks the acute warning function of physiological nociception.35 Usually pain is regarded as chronic when it…
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index
Genetic loci associated with body mass index map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor, which may provide new insights into human body weight regulation.
Genome Wide Association (GWA) Study for Early Onset Extreme Obesity Supports the Role of Fat Mass and Obesity Associated Gene (FTO) Variants
The authors' GWA for extreme early onset obesity substantiates that variation in FTO strongly contributes to early onset Obesity and is a further proof of concept for GWA to detect genes relevant for highly complex phenotypes.
Updates on the prevalence of body dysmorphic disorder: A population-based survey
The prevalence of body dysmorphic disorder: a population-based survey
- W. Rief, U. Buhlmann, S. Wilhelm, A. Borkenhagen, E. Brähler
- Medicine, PsychologyPsychological Medicine
- 6 March 2006
It is shown that self-reported Body dysmorphic disorder is relatively common and associated with significant morbidity, compared with individuals who did not meet criteria for BDD.
Correlates and long-term consequences of poor insight in patients with schizophrenia. A systematic review.
A critical review of 88 studies on the assessment of insight and its impact on symptoms and functioning finds a positive cross-sectional and longitudinal relationship between insight and depression, but the underlying processes need further clarification.
Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)
In conditions such as fibromyalgia or nonspecific low-back pain, chronic pain may be conceived as a disease in its own right; in this proposal, this subgroup is called “chronic primary pain,” and in 6 other subgroups, pain is secondary to an underlying disease.
The placebo response in medicine: minimize, maximize or personalize?
- P. Enck, U. Bingel, M. Schedlowski, W. Rief
- Psychology, MedicineNature Reviews Drug Discovery
- 1 March 2013
Three strategies that could be used to modulate the placebo response, depending on which stage of the drug development process they are applied are discussed.