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A Potential New Pathway for Staphylococcus aureus Dissemination: The Silent Survival of S. aureus Phagocytosed by Human Monocyte-Derived Macrophages
Although considered to be an extracellular pathogen, Staphylococcus aureus is able to invade a variety of mammalian, non-professional phagocytes and can also survive engulfment by professionalExpand
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Interaction of quorum signals with outer membrane lipids: insights into prokaryotic membrane vesicle formation
Bacteria have evolved elaborate communication strategies to co‐ordinate their group activities, a process termed quorum sensing (QS). Pseudomonas aeruginosa is an opportunistic pathogen that utilizesExpand
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High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase.
The smaller isoform of the GABA-synthesizing enzyme, glutamic acid decarboxylase 65 (GAD65), is unusually susceptible to becoming a target of autoimmunity affecting its major sites of expression,Expand
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Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils.
The formation of amyloid fibrils and other polypeptide aggregates depends strongly on the physico-chemical environment. One such factor affecting aggregation is the presence and concentration of saltExpand
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Interaction of LL-37 with model membrane systems of different complexity: influence of the lipid matrix.
As the main difference between bacterial and mammalian cell membranes is their net charge, the focal point of consideration in many model membrane experiments with antimicrobial peptides is lipidExpand
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Visualizing the structure of triglyceride nanoparticles in different crystal modifications.
Colloidal suspensions of triglycerides are under investigation as potential drug carrier systems. The properties of the matrix lipids are altered in the nanoparticles compared to those of the bulkExpand
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Hemolysis of human erythrocytes with saponin affects the membrane structure.
Incubation of cells and tissues with saponin makes the lipid bilayer permeable to macromolecules. Ghosts (membrane preparations) of saponin-lysed erythrocytes do not reseal, thus indicating anExpand
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Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides.
Bacterial endotoxins (lipopolysaccharides (LPS)) are strong elicitors of the human immune system by interacting with serum and membrane proteins such as lipopolysaccharide-binding protein (LBP) andExpand
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Belt-like localisation of caveolin in deep caveolae and its re-distribution after cholesterol depletion
Caveolae are specialised vesicular microdomains of the plasma membrane. Using freeze-fracture immunogold labelling and stereoscopic imaging, the distribution of labelled caveolin 1 in caveolae ofExpand
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Interactions of Mycobacterium fortuitum with solid sterol substrate particles
Mycobacterium fortuitum NRRL B‐8119 transformes sterols into 9 alpha‐hydroxy‐androsta‐4‐ene‐3,17‐dione (9OH‐AD) at high efficieny. Cells strongly aggregate to the surface of the sterol particlesExpand
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