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A short amino acid sequence able to specify nuclear location
By reducing the size of the transposed sequence, it is concluded that Pro-Lys- lys- Lys-Arg-L Lys-Val can act as a nuclear location signal and may represent a prototype of similar sequences in other nuclear proteins. Expand
Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
It is shown, by Cre-lox fate mapping in transgenic mice, that the first OLPs originate in the medial ganglionic eminence (MGE) and anterior entopeduncular area (AEP) in the ventral forebrain, and that functionally redundant populations of OLPs compete for space in the developing brain. Expand
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
The fates of adult OLPs are followed in Pdgfra-creERT2/Rosa26-YFP double-transgenic mice and it is found that they generated many myelinating oligodendrocytes during adulthood, but there is no evidence for astrocyte production in gray or white matter. Expand
Cell death and control of cell survival in the oligodendrocyte lineage
It is shown that about 50% of oligodendrocytes normally die in the developing rat optic nerve, apparently as a result of a competition for limiting amounts of survival signals and that a requirement for survival signals is more general than previously thought. Expand
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
It is concluded that adult-born OLs in the optic nerve are engaged in myelin remodeling, either replacing OLs that die in service or intercalating among existing myelin sheaths, which would predict that average internode length should decrease with age. Expand
Sequence requirements for nuclear location of simian virus 40 large-T antigen
A point mutation in the simian virus 40 large-T gene, which was generated by mixed oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a large-T antigen that wasExpand
Subventricular Zone Stem Cells Are Heterogeneous with Respect to Their Embryonic Origins and Neurogenic Fates in the Adult Olfactory Bulb
Different SVZ stem cells have different embryonic origins, colonize different parts of the SVZ, and generate different neuronal progeny, suggesting that some aspects of embryonic patterning are preserved in the adult SVZ. Expand
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
This work has used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. Expand
Neural crest origins of the neck and shoulder
The skeleton that is identified as neural crest-derived is specifically affected in human Klippel–Feil syndrome, Sprengel's deformity and Arnold–Chiari I/II malformation, providing insights into their likely aetiology. Expand
Oligodendrocyte Population Dynamics and the Role of PDGF In Vivo
Experiments with transgenic mice show that platelet-derived growth factor (PDGF) drives progenitor cell division and suggest that slowing of and exit from the cycle reflects a decline in PDGF signaling. Expand