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Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biology.
I. Forward One of the most important contributions to the vitamin D field has been the discovery by Wasserman and Taylor in 1966 (1) of vitamin D-dependent calcium binding protein [calbindin-D (2)].Expand
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Phosphoinositide metabolism and insulin secretion from isolated rat pancreatic islets.
Since many cell types have been shown to respond to extracellular stimulation with a rapid increase in phosphatidylinositol turnover, the present studies were undertaken to determine whetherExpand
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Immunocytochemical localization of vitamin D-dependent calcium binding protein in mammalian nephron.
Immunoreactive calcium binding protein (iCaBP) has been localized in the rat nephron using the unlabeled antibody peroxidase-antiperoxidase immunocytochemical technique. Kidneys from normal youngExpand
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Calbindin-D(28k) controls [Ca(2+)](i) and insulin release. Evidence obtained from calbindin-d(28k) knockout mice and beta cell lines.
The role of the calcium-binding protein, calbindin-D(28k) in potassium/depolarization-stimulated increases in the cytosolic free Ca(2+) concentration ([Ca(2+)](i)) and insulin release wasExpand
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Rat calbindin D28K: purification, quantitation, immunocytochemical localization, and comparative aspects.
Publisher Summary The purification, and biochemical and immunological characterization of vitamin D-dependent rat renal CaBP have only recently been reported. These biochemical and immunologicalExpand
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1,25-Dihydroxyvitamin D3 evokes oscillations of intracellular calcium in a pancreatic beta-cell line.
The steroid hormone 1 alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] can elicit biological responses via a nongenomic pathway that involves rapid opening of the plasma membrane Ca2+ channels. There isExpand
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Presence and localization of two vitamin D-dependent calcium binding proteins in kidneys of higher vertebrates.
We looked for the presence of vitamin D-dependent intestinal calcium binding protein (CaBP), relative molecular mass (mol wt) about 10,000, in kidneys of mammals, birds, and reptiles, and comparedExpand
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Vitamin A deficiency impairs fetal islet development and causes subsequent glucose intolerance in adult rats.
To determine the role of vitamin A in fetal islet development, beta- and alpha-cell mass, apoptosis, and alpha- and beta-cell replication were measured in rats using a model of marginal vitamin AExpand
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Vitamin D and intracellular calcium.
The role of the hormonally active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], in the regulation of Ca2+ metabolism is well established (Norman, 1979; Spirichev and Sergeev, 1988).Expand
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Light and electron microscopic studies on pancreatic islets of the lizard Lygosoma laterale. I. Normal and glucose-loaded animals.
  • W. Rhoten
  • Biology, Medicine
  • General and comparative endocrinology
  • 1 August 1971
Abstract The pancreatic islets from fasted and glucose-stimulated Lygosoma laterale were studied by light and electron microscopy. In the light microscope, A cells were elongate and containedExpand
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