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Cell Culture of Taxus as a Source of the Antineoplastic Drug Taxol and Related Taxanes
Callus cultures of Taxus cuspidata and Taxus canadensis were induced using different tissue explants including green and red arils, seed contents, young stems and needles to inhibit callus darkening and subsequent growth reduction.
Using NMR to identify and characterize natural products.
This review will focus on mainly methodology improvements, particularly in pulse sequences, acquisition and processing methods which are particularly relevant to natural product research, with lesser discussion of hardware improvements.
Assignment of 1H and 13C spectra and investigation of hindered side‐chain rotation in lupeol derivatives †
Complete 1H and 13C spectral assignments are reported for lupeol (1a) and two derivatives where the C‐30 methyl group is replaced by CH2OH (1b) and HC O (1c). Compound 1c shows conformationally
Isolation and identification by 2D NMR of two new complex saponins from Michrosechium helleri
Two complex saponins, amole F and G, were characterized and their spectra were assigned using only 1D and 2D 1H and NMR methods. Amole F and G have seven and six monosaccharides, respectively, linked
Bonducellpins A−D, New Cassane Furanoditerpenes of Caesalpinia bonduc
Four cassane furanoditerpenes, designated bonducellpins A, B, C, and D, were isolated from the roots of Caesalpinia bonduc by using a combination of 2D NMR experiments, which included COSY, HMQC, HMBC, and NOESY sequences.
Steroid hydroxylation by Whetzelinia sclerotiorum, Phanerochaete chrysosporium and Mucor plumbeus
Of the fungi investigated W. sclerotiorum performed the most interesting biotransformations and had a clear propensity for 2beta, 6beta/7beta and 15beta/16beta hydroxylations.
Friedeland Triterpenoids from Peritassa compta: Complete 1H and 13C Assignments by 2D nmr Spectroscopy
An investigation of the stems and bark of Peritassa compta has led to the isolation of three new natural products, friedelane-3,15-dione [3], 15α-hydroxyfriedelin [4], and