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Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) trial.
Focal impulse and rotor modulation elimination at patient-specific sources acutely terminated or slowed AF, and improved outcome are offered and offer a novel mechanistic framework and treatment paradigm for AF. Expand
Quantitative phase-field modeling of dendritic growth in two and three dimensions
We report the results of quantitative phase-field simulations of the dendritic crystallization of a pure melt in two and three dimensions. These simulations exploit a recently developedExpand
Self-organization in systems of self-propelled particles.
A continuum version of the discrete model consisting of self-propelled particles that obey simple interaction rules is developed and it is demonstrated that the agreement between the discrete and the continuum model is excellent. Expand
Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway
The dynamical response to a uniform change in chemoattractant concentration of a eukaryotic chemotaxis pathway immediately downstream from G protein–coupled receptors is determined. Expand
CO2 Sensing and CO2 Regulation of Stomatal Conductance: Advances and Open Questions.
Evidence suggests that plants can sense [CO2] changes via guard cells and via mesophyll tissues in mediating stomatal movements, and together function in the CO2 regulation ofStomatal conductance and gas exchange in plants. Expand
Directional sensing in eukaryotic chemotaxis: a balanced inactivation model.
This work proposes a directional sensing mechanism in which two second messengers are produced at equal rates and proposes that the dynamics of a heterotrimeric G protein might allow for a specific biochemical realization of this model. Expand
Clinical Mapping Approach To Diagnose Electrical Rotors and Focal Impulse Sources for Human Atrial Fibrillation
A clinical computational mapping approach is developed, guided by human atrial tissue physiology, to reveal sources of human AF. Expand
Dictyostelium discoideum chemotaxis: threshold for directed motion.
The chemotactic response of Dictyostelium discoideum cells to stationary, linear gradients of cyclic adenosine 3',5'-monophosphate (cAMP) was studied using microfluidic devices. In shallow gradientsExpand
Membrane-bound Turing patterns.
  • H. Levine, W. Rappel
  • Mathematics, Medicine
  • Physical review. E, Statistical, nonlinear, and…
  • 19 December 2005
This work studies Turing patterns in bounded regions where the nonlinear chemical reactions occur on the boundary and where reagent transport occurs in the bulk to find that Turing patterns exist even in the case of equal diffusion constants. Expand
The physics of eukaryotic chemotaxis.
Cells sense chemical gradients, communicate gradient information throughout the cell, and change their shape in response, and underlie thoseessential biological processes. Expand