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The medaka draft genome and insights into vertebrate genome evolution
Teleosts comprise more than half of all vertebrate species and have adapted to a variety of marine and freshwater habitats. Their genome evolution and diversification are important subjects for theExpand
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Role of oxidative stress in cadmium toxicity and carcinogenesis.
Cadmium (Cd) is a toxic metal, targeting the lung, liver, kidney, and testes following acute intoxication, and causing nephrotoxicity, immunotoxicity, osteotoxicity and tumors after prolongedExpand
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Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation.
Cadmium is a human carcinogen that likely acts via epigenetic mechanisms. Since DNA methylation alterations represent an important epigenetic event linked to cancer, the effect of cadmium on DNAExpand
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Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy
Epilepsy is a common neurological disorder, and mutations in genes encoding ion channels or neurotransmitter receptors are frequent causes of monogenic forms of epilepsy. Here we show that abnormalExpand
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Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide.
Inorganic arsenic is a well-documented human carcinogen that targets the skin. The induction of oxidative stress, as shown with arsenic, may have a bearing on the carcinogenic mechanism of thisExpand
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HMM-based motion recognition system using segmented PCA
We propose a novel technique for model-based recognition of complex object motion trajectories using hidden Markov models (HMM). Expand
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Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2.
Arsenic is a well-known human skin carcinogen but the underlying mechanisms of carcinogenesis are unclear. Transcription factor Nrf2-mediated antioxidant response represents a critical cellularExpand
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The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells.
As the primary physiological barrier, intestinal epithelial cells regulate the transportation of oral therapeutic agents including nanomedicines which significantly improves the bioavailability ofExpand
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Lung tumors in mice induced by “whole-life” inorganic arsenic exposure at human-relevant doses
Abstract In mice, inorganic arsenic in the drinking water in the parts per million range via the dam during in utero life or with whole-life exposure is a multi-site carcinogen in the offspring.Expand
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Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: a resting-state fMRI study.
BACKGROUND Abnormality of orbitofronto-striatal circuits was postulated in obsessive-compulsive disorder (OCD). The aim of this study is to test the abnormality hypothesis of orbitofronto-striatalExpand
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