Share This Author
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
By using gene editing to simultaneously introduce the CAR and disrupt TCR and CD52 in T cells, the authors generated functional CAR T cells that could evade host immunity for use in unmatched recipients and demonstrates the therapeutic potential of gene-editing technology.
Human Coronavirus OC43 Associated with Fatal Encephalitis.
- S. Morfopoulou, Julianne R. Brown, J. Breuer
- Medicine, PsychologyNew England Journal of Medicine
- 3 August 2016
In this case report, severe encephalitis with no established cause developed in a child with SCID. Through deep sequencing, human coronavirus OC43 was identified in brain tissue.
Omission of in vivo T‐cell depletion promotes rapid expansion of naïve CD4+ cord blood lymphocytes and restores adaptive immunity within 2 months after unrelated cord blood transplant
The omission of in vivo T‐cell depletion promotes a unique thymic‐independent CD4+ T‐ cell reconstitution after unrelated UCBT in children, and it is postulate that this relates to the specific immunological and ontological qualities of fetal‐derived lymphocytes.
Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient.
How I treat severe combined immunodeficiency.
The development of autologous hematopoietic stem cell gene therapy provides another treatment of the X-linked and adenosine deaminase-deficient forms of SCID, and it is discussed how this treatment strategy has integrated gene therapy into the treatment strategy.
FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy.
This paper presents a meta-analyses of the Y.R.D.S.C.A.H.Y. gene constructions that show clear patterns in the response of the immune system to EMTs to treat central nervous system disorders.
Production and First-in-Man Use of T Cells Engineered to Express a HSVTK-CD34 Sort-Suicide Gene
These findings highlight the suitability of tCD34 as a GMP compliant selection marker and demonstrate the feasibility, safety and immunological potential of HSVTK-tCD34 suicide gene modified donor T cells.
Long-term outcome and lineage-specific chimerism in 194 patients with Wiskott-Aldrich syndrome treated by hematopoietic cell transplantation in the period 1980-2009: an international collaborative…
Retrospective analysis of lineage-specific donor cell engraftment showed that stable full donor chimerism was attained by 72.3% of the patients who survived for at least 1 year after HCT, indicating continuous improvement of outcome after hematopoietic cell transplantation for WAS.
Astrovirus VA1/HMO-C: An Increasingly Recognized Neurotropic Pathogen in Immunocompromised Patients
Brain biopsy from a child with unknown cause of encephalopathy was deep-sequenced, and findings suggest astrovirus VA1/HMO-C is an under-recognized cause of viral encephalitis.
Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two phase 1 studies