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Simultaneous determination of ethylene glycol and glycolic acid in serum by gas chromatography-mass spectrometry.
We describe a gas chromatographic-mass spectrometric (GC-MS) procedure for the simultaneous determination of ethylene glycol (EG) and its major toxic metabolite, glycolic acid (GA), in serum. In this… Expand
Simultaneous determination of ethylene glycol and its major toxic metabolite, glycolic acid, in serum by gas chromatography.
We developed a gas-chromatographic procedure for the simultaneous determination of ethylene glycol (EG) and its major toxic metabolite, glycolic acid (GA), suitable for clinical use in instances of… Expand
Ethylene Glycol Toxicity: The Role of Serum Glycolic Acid In Hemodialysis
- W. Porter, P. Rutter, B. Bush, A. Pappas, J. E. Dunnington
- Medicine
- Journal of toxicology. Clinical toxicology
- 1 January 2001
Objective: To correlate serum glycolic acid levels with clinical severity and outcome in ethylene glycol poisoning and to determine if glycolic acid levels are predictive of renal failure and the… Expand
Interference by glycolic acid in the Beckman synchron method for lactate: a useful clue for unsuspected ethylene glycol intoxication.
- W. Porter, M. Crellin, P. Rutter, P. Oeltgen
- Medicine, Chemistry
- Clinical chemistry
- 1 June 2000
In the differential evaluation of patients with high anion gap metabolic acidosis of unknown origin, lactate determinations are frequently performed. For patients who ingest ethylene glycol (present… Expand
Ethylene glycol poisoning: quintessential clinical toxicology; analytical conundrum.
- W. Porter
- Medicine
- Clinica chimica acta; international journal of…
- 2012
Ethylene glycol poisoning is a medical emergency that presents challenges both for clinicians and clinical laboratories. Untreated, it may cause morbidly or death, but effective therapy is available,… Expand
gamma-Hydroxybutyrate intoxication and overdose.
- F. P. Kohrs, W. Porter
- Medicine
- Annals of emergency medicine
- 1999
Gas-chromatographic determination of ethylene glycol in serum.
- W. Porter, A. Auansakul
- Medicine, Chemistry
- Clinical chemistry
- 1982
We describe a new gas-chromatographic procedure for ethylene glycol in serum, determined as the cyclic phenylboronate ester. The method is rapid, requires only 100 microL of serum, and either an OV-1… Expand
Elevated lactate in ethylene glycol poisoning: True or false?
- Q. Meng, K. Adeli, G. Zello, W. Porter, J. Krahn
- Chemistry, Medicine
- Clinica chimica acta; international journal of…
- 2 April 2010
BACKGROUND
There have been an increasing number of reports on false increase of lactate in ethylene glycol poisoning. We recently encountered two cases of ethylene glycol poisoning with very high… Expand
Hemodialysis clearance of pentobarbital during continuous infusion.
- D. Wermeling, K. Record, R. Bell, W. Porter, R. Blouin
- Medicine
- Therapeutic drug monitoring
- 1985
The hemodialysis clearance of pentobarbital during continuous infusion was determined in a 34-year-old man in acute renal failure. Pentobarbital specimens were obtained simultaneously from arterial… Expand
Application of nitrous acid deamination of hexosamines to the simultaneous GLC determination of neutral and amino sugars in glycoproteins.
- W. Porter
- Chemistry, Medicine
- Analytical biochemistry
- 1975
Abstract A method is described for simultaneous gas chromatographic analysis of neutral sugars and hexosamines in glycoproteins. Sugars are hydrolyzed with the aid of Dowex 50-X2 (H + ) resin and the… Expand