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  • Influence
A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease.
To identify rare causal variants in late-onset Parkinson disease (PD), we investigated an Austrian family with 16 affected individuals by exome sequencing. We found a missense mutation, c.1858G>AExpand
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Imaging serotonin and dopamine transporters with 123I-beta-CIT SPECT: binding kinetics and effects of normal aging.
UNLABELLED [123I]beta-carbomethoxy-3-beta-(4-iodophenyl)-tropane (CIT) is a useful ligand for dopamine transporters (DATs) and serotonin transporters (5-HTTs). Previous SPECT studies have shown aExpand
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Correlation of dopamine transporter imaging with parkinsonian motor handicap: How close is it?
  • W. Pirker
  • Medicine, Psychology
  • Movement disorders : official journal of the…
  • 1 October 2003
During the past decade, dopamine transporter (DAT) imaging with single photon emission computerized tomography (SPECT) or positron emission tomography (PET) has evolved as an objective in vivo markerExpand
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The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PD Study)
Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor symptoms. Relationship between premotor symptoms onset and motor features is limited. Our aim is to describe theExpand
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Progression of dopaminergic degeneration in Parkinson's disease and atypical parkinsonism: A longitudinal β‐CIT SPECT study
Atypical parkinsonian syndromes (APS) such as multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration are characterized by poor response to antiparkinsonian medicationExpand
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Measurement of the dopaminergic degeneration in Parkinson's disease with [123I] beta-CIT and SPECT. Correlation with clinical findings and comparison with multiple system atrophy and progressive
The cocaine derivative [123I] beta-CIT binds with high affinity to dopamine uptake sites in the striatum and can be used to visualize dopaminergic nerve terminals in vivo in the human brain withExpand
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[123I] β-CIT and single photon emission computed tomography reveal reduced brain serotonin transporter availability in bulimia nervosa
BACKGROUND Impaired serotonin transmission has been implicated in the pathophysiology of eating disorders. We investigated the in vivo availability of brain serotonin transporters and dopamineExpand
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[123I]β‐CIT spect in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration
Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), andExpand
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SPECT and PET imaging of the dopaminergic system in Parkinson's disease
Summary This paper gives an overview of the clinical importance of SPECT and PET imaging of the dopaminergic system in the differential diagnosis and for the determination of the progression rate ofExpand
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Immediate, non-submerged, root-analogue zirconia implant in single tooth replacement.
  • W. Pirker, A. Kocher
  • Medicine
  • International journal of oral and maxillofacial…
  • 1 March 2008
This report demonstrates the successful clinical use of a modified root-analogue zirconia implant for immediate single tooth replacement. A right maxillary premolar was removed and a custom-made,Expand
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