Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice
- A. Livanos, T. Greiner, M. Blaser
- Biology, MedicineNature Microbiology
- 22 August 2016
Findings show that early-life antibiotic treatments alter the gut microbiota and its metabolic capacities, intestinal gene expression and T-cell populations, accelerating T1D onset in non-obese diabetic mice.
Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity
- Xue-Song Zhang, Jackie Li, M. Blaser
- Biology, MedicineeLife
- 24 July 2018
This simplified animal model reveals multiple potential pathways to understand pathogenesis by which early-life gut microbiome perturbations alter a global suite of intestinal responses, contributing to the accelerated and enhanced T1D development.
The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes
- Anjelique F. Schulfer, Jonas Schluter, M. Blaser
- BiologyThe ISME Journal
- 16 January 2019
It is shown that cohousing can partly ameliorate the impact of STAT on the gut microbiota but not prevent increased weight with high-fat diet, which has implications for microbiota therapies aimed to resolve the collateral damage of antibiotics and their load on human obesity.
Distribution and biomarker of carbon‐14 labeled fullerene C60 ([14C(U)]C60) in pregnant and lactating rats and their offspring after maternal intravenous exposure
- R. Snyder, T. Fennell, S. Sumner
- BiologyJournal of Applied Toxicology
- 1 December 2015
Metabolomics analysis of urine showed that [14C(U)]C60 exposure to pregnant rats impacted the pathways of vitamin B, regulation of lipid and sugar metabolism and aminoacyl‐tRNA biosynthesis, and is transferred to pups via milk.
Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function
- Y. Sandlers, K. Mercier, H. Vernon
- Biology, MedicinePLoS ONE
- 25 March 2016
Analysis of metabolite profiles in plasma from a cohort of individuals with Barth Syndrome compared to age-matched controls indicates broad metabolic dysregulation in Barth Syndrome with wide cellular effects.
Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice
- Magdalena Mazagova, Lirui Wang, Bernd Scmiabl
- Biology, MedicineThe FASEB Journal
- 1 March 2015
This is the first study describing a beneficial role of the commensal microbiota in maintaining liver homeostasis and preventing liver fibrosis in mice and the commenal microbiota prevents fibrosis upon chronic liver injury in mice.
Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.
- S. Barnes, H. P. Benton, H. Tiwari
- PhysicsJournal of Mass Spectrometry
- 1 July 2016
Recognizing the experimental challenges confronting researchers who undertake metabolism studies, workshops like the one at University of Alabama at Birmingham have been established to offer instructional guidance.
Preterm neonatal urinary renal developmental and acute kidney injury metabolomic profiling: an exploratory study
- K. Mercier, S. McRitchie, S. Sumner
- Medicine, BiologyPediatric nephrology (Berlin, West)
- 2016
Metabolomics was able to differentiate the urinary profiles of neonates with and without an AKI diagnosis and metabolic developmental profiles correlated with gestational age and only the metabotype was a significant predictor of AKI.
High-quality oligo-RNA synthesis using the new 2′-O-TEM protecting group by selectively quenching the addition of p-tolyl vinyl sulphone to exocyclic amino functions
- Chuanzheng Zhou, W. Pathmasiri, D. Honcharenko, S. Chatterjee, J. Barman, J. Chattopadhyaya
- Chemistry
- 1 April 2007
During the F--promoted deprotection of the oligo-RNA, synthesized using our 2′-O-(4-tolylsulfonyl)ethoxymethyl (2′-O-TEM) group [Org. Biomol. Chem. 5, 333 (2007)], p-tolyl vinyl sulphone (TVS) is f…
Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data.
- S. Barnes, H. P. Benton, H. Tiwari
- Environmental ScienceJournal of Mass Spectrometry
- 1 July 2016
The first part of a summary of the training materials presented in the course to be used as a resource for all those embarking on metabolomics research are presented.
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