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Transport of brain-derived neurotrophic factor across the blood–brain barrier
Brain-derived neurotrophic factor (BDNF) is a potential therapeutic agent for degenerative disorders of the central nervous system. In this report, we investigated the ability of BDNF to cross theExpand
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Differential BBB interactions of three ingestive peptides: Obestatin, ghrelin, and adiponectin
Endogenous compounds, including ingestive peptides, can interact with the blood-brain barrier (BBB) in different ways. Here we used in vivo and in vitro techniques to examine the BBB permeation ofExpand
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Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain barrier
AbstractGlucagon-like peptide-1 (GLP-1) reduces insulin requirement in diabetes mellitus and promotes satiety. GLP-1 in the periphery (outside the CNS) has been shown to act on the brain to reduceExpand
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The fasting polypeptide FGF21 can enter brain from blood
FGF21 recently has been proposed as a missing link in the biology of fasting, raising the question of whether it directly reaches the brain. We used multiple time-regression analysis to quantify theExpand
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Obesity induces functional astrocytic leptin receptors in hypothalamus.
  • Hung Hsuchou, Yi He, +5 authors W. Pan
  • Biology, Medicine
  • Brain : a journal of neurology
  • 21 May 2008
The possible role of astrocytes in the regulation of feeding has been overlooked. It is well-established that the endothelial cells constituting the blood-brain barrier transport leptin from blood toExpand
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Sleep Restriction Impairs Blood–Brain Barrier Function
The blood–brain barrier (BBB) is a large regulatory and exchange interface between the brain and peripheral circulation. We propose that changes of the BBB contribute to many pathophysiologicalExpand
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Soluble receptor inhibits leptin transport
Evidence both from mice and cultured cells suggests an important role of soluble leptin receptors in obesity and leptin signaling. However, the direct effects of soluble receptors on leptin uptake byExpand
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Neuroinflammation facilitates LIF entry into brain: role of TNF.
Leukemia inhibitory factor (LIF) is a proinflammatory cytokine mediating a variety of central nervous system (CNS) responses to inflammatory stimuli. During lipopolysaccharide (LPS)-inducedExpand
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Decreased transport of leptin across the blood–brain barrier in rats lacking the short form of the leptin receptor☆
Leptin is produced in adipose tissue in the periphery, but its satiety effect is exerted in the CNS that it reaches by a saturable transport system across the blood-brain barrier (BBB). The shortExpand
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Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors
ABSTRACT Ras leads an important signaling pathway that is deregulated in neurofibromatosis type 1 and malignant peripheral nerve sheath tumor (MPNST). In this study, we show that overactivation ofExpand
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