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Silicon Analogues of the RXR‐Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology
TLDR
Twofold sila‐substitution (C/Si exchange) in the RXR‐selective retinoids 4’a and 5 a leads to 4 b (disila‐SR11237) and 5'b, respectively.
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Sila-Trifluperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Trifluperidol: Synthesis and Pharmacological Characterization
Trifluperidol (2a) is a dopamine (D2) receptor antagonist of the butyrophenone type. Carbon/silicon exchange (sila-substitution) in the 4-position of the piperidine ring of 2a (R3COH → R3SiOH)…
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New C-functionalized silacycloalkanes (CH2)nSi(CH2X)2 and (CH2)nSi(CH2X)CH2X′ (n = 3, 4; X, X′ = functional group): Synthesis and reactivity studies of analogous silacyclobutanes and silacyclopentanes
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Synthesis and Pharmacological Characterization of Disila‐AM80 (Disila‐tamibarotene) and Disila‐AM580, Silicon Analogues of the RARα‐Selective Retinoid Agonists AM80 (Tamibarotene) and AM580
TLDR
The synthesis of the silicon compounds 1 a and 2 b and the pharmacological characterization of the C/Si pairs 1 a/1 b and 2 a/ 2 b were performed as part of the systematic ACHTUNGTRENNUNGinvestigations on silicon-based drugs.
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Novel Silicon‐Containing Analogues of the Retinoid Agonist Bexarotene: Syntheses and Biological Effects on Human Pluripotent Stem Cells
TLDR
Preliminary evidence indicates that disila‐bexarotene and its analogues 8 and 9 may possess enhanced functions over the parent compound bexarotenes, such as induction and regulation of cell death and cell numbers.
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Zwitterionic and anionic multinuclear pentacoordinate silicon(IV) complexes with bridging (R,R)-tartrato(4-) ligands and SiO5 skeletons: synthesis and reactivity in aqueous solution.
TLDR
Two nutrients in one molecule: A zwitterionic λ( 5)Si,λ(5)Si'-disilicate (1) was synthesized and characterized and shows a remarkable kinetic stability in water.
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Inside Cover: Silicon Analogues of the RXR‐Selective Retinoid Agonist SR11237 (BMS649): Chemistry and Biology (ChemMedChem 7/2009)
The inside cover picture shows a carbon-based (left) and the analogous silicon-based (right) derivative of the highly potent pan-RXR-selective retinoid agonist SR11237. Switching from carbon to…
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