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Dopamine depletion impairs precursor cell proliferation in Parkinson disease
Cerebral dopamine depletion is the hallmark of Parkinson disease. Because dopamine modulates ontogenetic neurogenesis, depletion of dopamine might affect neural precursors in the subependymal zoneExpand
MDS clinical diagnostic criteria for Parkinson's disease
The Movement Disorder Society PD Criteria retain motor parkinsonism as the core feature of the disease, defined as bradykinesia plus rest tremor or rigidity, and two levels of certainty are delineated: clinically established PD and probable PD. Expand
A randomized trial of deep-brain stimulation for Parkinson's disease.
In this six-month study of patients under 75 years of age with severe motor complications of Parkinson's disease, neurostimulation of the subthalamic nucleus was more effective than medical management alone. Expand
The REM sleep behavior disorder screening questionnaire—A new diagnostic instrument
The RBDSQ appears to be particularly useful as a screening tool for patients with assumed idiopathic REM sleep behavior disorder, and poorly discriminated patients with the most challenging differential diagnoses such as sleepwalking or epilepsy. Expand
Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
It is concluded that injection of 6-hydroxydopamine into the terminal field of nigral dopaminergic neurons causes a progressive degeneration of these cells, starting between one and two weeks after lesion and continuing over eight to 16 weeks, yielding an animal model which mimics the degenerative processes in Parkinson's disease more closely than the animal models available so far. Expand
Toward a better definition of the restless legs syndrome
Features commonly seen in RLS include sleep disturbance, periodic limb movements in sleep and similar involuntary movements while awake, a normal neurological examination in the idiopathic from, a tendency for the symptoms to be worse in middle to older age, and, in some cases, a family history suggestive of an autosomal dominant mode of inheritance. Expand
Validation of the freezing of gait questionnaire in patients with Parkinson's disease
FOG‐Q was a reliable tool for the assessment of treatment intervention and was best correlated to items of the UPDRS relating to walking, general motor issues, and mobility. Expand
Prevalence and incidence of Parkinson's disease in Europe
The observed variations in prevalence and incidence rates may result from environmental or genetic factors, but might also be a consequence of differences in methodologies for case ascertainment, diagnostic criteria, or age distributions of the study populations. Expand
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
In vivo findings confirm that widespread microglial activation is associated with the pathological process in PD and suggest that microglia are activated early in the disease process, and levels then remain relatively static, possibly driving the disease via cytokine release. Expand
Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome. Expand