W. Obrist

Publications116
h-index40
Citations7,896
Highly Influential Citations181
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Cerebral blood flow and metabolism in comatose patients with acute head injury. Relationship to intracranial hypertension.
Cerebral blood flow (CBF) measurements were made in 75 adult patients with closed head injuries (mean Glasgow Coma Scale score 6.2) using the xenon-133 intravenous injection method with eight… Expand
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The use of moderate therapeutic hypothermia for patients with severe head injuries: a preliminary report.
Animal research suggests that moderate therapeutic hypothermia may improve outcome after a severe head injury, but its efficacy has not been established in humans. The authors randomly assigned 40… Expand
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Treatment of traumatic brain injury with moderate hypothermia.
BACKGROUND Traumatic brain injury initiates several metabolic processes that can exacerbate the injury. There is evidence that hypothermia may limit some of these deleterious metabolic responses. … Expand
  • 325
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Posttraumatic vasospasm: the epidemiology, severity, and time course of an underestimated phenomenon: a prospective study performed in 299 patients.
OBJECT The purpose of this prospective study was to evaluate the cumulative incidence, duration, and time course of cerebral vasospasm after traumatic brain injury (TBI) in a cohort of 299 patients.… Expand
  • 170
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Determination of Regional Cerebral Blood Flow by Inhalation of 133‐Xenon
A method for estimating regional cerebral blood flow is described in which tracer amounts of 133Xe are inhaled for 2 min and monitored extracranially over the next 45 to 60 min. A three-compartment… Expand
  • 387
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Sex and handedness differences in cerebral blood flow during rest and cognitive activity.
Cognitive activity resulted in increased flow of blood to the cerebral hemispheres. The increase was greater to the left hemisphere for a verbal task and greater to the right hemisphere for a spatial… Expand
  • 412
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Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury.
OBJECTIVES Despite the growing clinical use of brain tissue oxygen monitoring, the specific determinants of low brain tissue oxygen tension (P(bt)O2) following severe traumatic brain injury (TBI)… Expand
  • 66
  • 8
Cerebral hemodynamic and metabolic changes in fulminant hepatic failure: A retrospective study
The purpose of this retrospective study was to determine cerebral hemodynamic and metabolic changes in comatose patients with fulminant hepatic failure. Computerized tomography of the brain and… Expand
  • 137
  • 7
Relationship of early cerebral blood flow and metabolism to outcome in acute head injury.
Cerebral blood flow (CBF) measurements were obtained acutely in 96 comatose patients with closed head injury, using the intravenous 133Xe technique. Arteriojugular venous oxygen differences and… Expand
  • 232
  • 6
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Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury*
Objectives:Despite the growing clinical use of brain tissue oxygen monitoring, the specific determinants of low brain tissue oxygen tension (Pbto2) following severe traumatic brain injury (TBI)… Expand
  • 117
  • 6