W. Nierman

Publications212
h-index69
Citations23,651
Highly Influential Citations1,276
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DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
TLDR
The V. cholerae genomic sequence provides a starting point for understanding how a free-living, environmental organism emerged to become a significant human bacterial pathogen.
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Phylogenomics of the Reproductive Parasite Wolbachia pipientis wMel: A Streamlined Genome Overrun by Mobile Genetic Elements
TLDR
Genetic analysis of the wMel genome further supports the hypothesis that mitochondria share a common ancestor with the α-Proteobacteria, but shows little support for the grouping of mitochondria with species in the order Rickettsiales.
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SMURF: Genomic mapping of fungal secondary metabolite clusters.
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution
TLDR
This first comprehensive analysis of the genome sequence of the Brown Norway (BN) rat strain is reported, which is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution.
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Evolution of sensory complexity recorded in a myxobacterial genome
TLDR
It is suggested that gene duplication and divergence were major contributors to genomic expansion from its progenitor, and families of genes encoding the production of secondary metabolites are overrepresented in the genome but may have been received by horizontal gene transfer and are likely to be important for predation.
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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
TLDR
The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
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Genome sequencing and analysis of Aspergillus oryzae
TLDR
Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation.
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Complete genome sequence of Caulobacter crescentus
TLDR
C. crescentus is, to the authors' knowledge, the first free-living α-class proteobacterium to be sequenced and will serve as a foundation for exploring the biology of this group of bacteria, which includes the obligate endosymbiont and human pathogen Rickettsia prowazekii, the plant pathogen Agrobacterium tumefaciens, and the bovine andhuman pathogen Brucella abortus.
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Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
TLDR
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution, and a comparative study with Aspergillus fumigatus and As pergillus oryzae, used in the production of sake, miso and soy sauce, provides new insight into eukaryotic genome evolution and gene regulation.
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The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria
TLDR
Several chromosomally encoded proteins that may contribute to pathogenicity—including haemolysins, phospholipases and iron acquisition functions—and numerous surface proteins that might be important targets for vaccines and drugs are found.
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