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Soluble Host Defense Lectins in Innate Immunity to Influenza Virus
Host defenses against viral infections depend on a complex interplay of innate (nonspecific) and adaptive (specific) components. In the early stages of infection, innate mechanisms represent the mainExpand
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Treatment of urinary tract infection with gentamicin once or three times daily
Aim: To examine the safety and efficacy of once‐daily (OD) gentamicin treatment compared with conventional 8‐hourly dosing (TDS) for urinary tract infection (UTI). Methods: This was a prospective,Expand
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The Macrophage Galactose-Type Lectin Can Function as an Attachment and Entry Receptor for Influenza Virus
ABSTRACT Specific protein receptors that mediate internalization and entry of influenza A virus (IAV) have not been identified for any cell type. Sialic acid (SIA), the primary attachment factor forExpand
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Prevention and Treatment of Influenza with Hyperimmune Bovine Colostrum Antibody
Background Despite the availability of specific vaccines and antiviral drugs, influenza continues to impose a heavy toll on human health worldwide. Passive transfer of specific antibody (Ab) mayExpand
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Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN
The ubiquitous presence of cell-surface sialic acid (SIA) has complicated efforts to identify specific transmembrane glycoproteins that function as bone fide entry receptors for influenza A virusExpand
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Influenza‐induced, helper‐independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response
The helper‐dependent pathway of priming CD8+ T cells involves “licensing” of DCs by CD40L on CD4+ T cells. The helper‐independent (“helpless”) pathways elicited by many viruses, including influenza,Expand
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The 5′ and 3′ Untranslated Regions of the Flaviviral Genome
Flaviviruses are enveloped arthropod-borne viruses with a single-stranded, positive-sense RNA genome that can cause serious illness in humans and animals. The 11 kb 5′ capped RNA genome consists of aExpand
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Respiratory DC Use IFITM3 to Avoid Direct Viral Infection and Safeguard Virus-Specific CD8+ T Cell Priming
Respiratory dendritic cells (DC) play a pivotal role in the initiation of adaptive immune responses to influenza virus. To do this, respiratory DCs must ferry viral antigen from the lung to theExpand
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Identification and characterization of host proteins bound to dengue virus 3' UTR reveal an antiviral role for quaking proteins.
The four dengue viruses (DENV1-4) are rapidly reemerging infectious RNA viruses. These positive-strand viral genomes contain structured 3' untranslated regions (UTRs) that interact with various hostExpand
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A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses.
OBJECTIVES Emerging drug resistance to antiviral therapies is an increasing challenge for the treatment of influenza virus infections. One new antiviral compound, BTA938, a dimeric derivative of theExpand
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