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Protein expression changes in the nucleus accumbens and amygdala of inbred alcohol-preferring rats given either continuous or scheduled access to ethanol.
Chronic ethanol (EtOH) drinking produces neuronal alterations within the limbic system. To investigate changes in protein expression levels associated with EtOH drinking, inbred alcohol-preferringExpand
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Functional gene expression differences between inbred alcohol-preferring and -non-preferring rats in five brain regions.
The objective of this study was to determine if there are innate differences in gene expression in selected CNS regions between inbred alcohol-preferring (iP) and -non-preferring (iNP) rats. GeneExpand
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Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption
The objective of this study was to determine the effects of binge-like alcohol drinking on gene expression changes in the nucleus accumbens (ACB) of alcohol-preferring (P) rats. Adult male P ratsExpand
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α-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats
Total gene expression analysis (TOGA) was used to identify genes that are differentially expressed in brain regions between the alcohol-naïve, inbred alcohol-preferring (iP), and -nonpreferring (iNP)Expand
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Candidate genes, pathways and mechanisms for alcoholism: an expanded convergent functional genomics approach
We describe a comprehensive translational approach for identifying candidate genes for alcoholism. The approach relies on the cross-matching of animal model brain gene expression data with humanExpand
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Alcohol effects on central nervous system gene expression in genetic animal models.
This article summarizes the proceedings of a symposium presented at the 2004 annual meeting of the Research Society on Alcoholism in Vancouver, British Columbia, Canada. The organizers and chairsExpand
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Proteomics and alcoholism.
Publisher Summary This chapter discusses the role of proteomics in alcoholism. Challenges in the alcohol research community continue to focus on how alcohol modifies the brain structure and functionExpand
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Innate differences in protein expression in the nucleus accumbens and hippocampus of inbred alcohol‐preferring and ‐nonpreferring rats
Two‐dimensional gel electrophoresis (2‐DE) was used to separate protein samples solubilized from the nucleus accumbens and hippocampus of alcohol‐naïve, adult, male inbred alcohol‐preferring (iP) andExpand
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Dopamine and serotonin content in select brain regions of weanling and adult alcohol drinking rat lines
The objective of the present study was to examine innate differences in the tissue content of dopamine (DA), serotonin (5-HT) and their metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC),Expand
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Drd2 expression in the high alcohol-preferring and low alcohol-preferring mice
The high alcohol-preferring (HAP) and low alcohol-preferring (LAP) mice were selectively bred for differences in alcohol preference and consumption. Recently, a large-effect QTL was identified onExpand
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