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Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  • W. Muller
  • Biology, Medicine
  • Trends in immunology
  • 1 June 2003
Both the innate and adaptive immune responses are dependent on the migration of leukocytes across endothelial cells. The process of diapedesis, in which the leukocyte crawls between tightly apposedExpand
  • 774
  • 34
The Abundant NK Cells in Human Secondary Lymphoid Tissues Require Activation to Express Killer Cell Ig-Like Receptors and Become Cytolytic1
Natural killer cells are important cytolytic cells in innate immunity. We have characterized human NK cells of spleen, lymph nodes, and tonsils. More than 95% of peripheral blood and 85% of spleen NKExpand
  • 579
  • 33
Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking.
Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The originExpand
  • 895
  • 31
CD99 plays a major role in the migration of monocytes through endothelial junctions
CD99 is a heavily O-glycosylated 32-kD type I transmembrane protein that is expressed on most hematopoietic cells. We show here that CD99 is expressed on endothelial cells and is concentrated at theExpand
  • 487
  • 30
Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
Dendritic cells (DCs) are known to induce the growth and function of natural killer (NK) cells. Here, we address the capacity of DCs to interact with NK cells in human lymphoid organs and identifyExpand
  • 541
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Differentiation of phagocytic monocytes into lymph node dendritic cells in vivo.
We investigated the differentiation and trafficking of inflammatory monocytes that phagocytosed subcutaneously injected fluorescent microspheres. As expected, most of the monocytes becameExpand
  • 987
  • 24
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell proteinExpand
  • 922
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PECAM-1 is required for transendothelial migration of leukocytes
Platelet/endothelial cell adhesion molecule 1 (PECAM-1; CD31) is crucial to the process of leukocyte transmigration through intercellular junctions of vascular endothelial cells. A monoclonalExpand
  • 1,162
  • 21
  • PDF
Locomotion of monocytes on endothelium is a critical step during extravasation
Monocytes, like all leukocytes, undergo a series of sequential steps during extravasation from blood into tissues: tethering, rolling, adhesion and diapedesis. We have discovered an essential step,Expand
  • 416
  • 21
Endocytosis and the recycling of plasma membrane
The study of endocytosis has traditionally focused on the contents of endocytic vacuoles, i.e., extracellular fluid, dissolved solutes, and macromolecules or particles which specifically orExpand
  • 1,284
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