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Amyloid heart disease. New frontiers and insights in pathophysiology, diagnosis, and management.
Amyloidosis comprises a unique group of diseases that share in common the extracellular deposition of insoluble fibrillar proteins in organs and tissues. Cardiovascular amyloidosis can be primary, aExpand
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Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells.
BACKGROUND Intravenous immunoglobulin (IVIg) is a polyclonal IgG preparation with potent immunomodulating properties. Our laboratory demonstrated that IVIg significantly increases numbers of forkheadExpand
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The crystal structure of staphylococcal enterotoxin type D reveals Zn2+‐mediated homodimerization.
Bacterial superantigens, including the staphylococcal enterotoxins, are the most potent activators of T cells known and have been suggested as a causative factor in Gram‐positive shock in humans.Expand
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Mek2 Is Dispensable for Mouse Growth and Development
ABSTRACT MEK is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) mitogen-activated protein (MAP) kinase upon agonist binding to receptors. The ERK/MAP kinaseExpand
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CD40 ligand binds to alpha5beta1 integrin and triggers cell signaling.
It was originally thought that the critical role of the CD40 ligand (CD40L) in normal and inflammatory immune responses was mainly mediated through its interaction with the classic receptor, CD40.Expand
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CD154 Is Released from T-cells by a Disintegrin and Metalloproteinase Domain-containing Protein 10 (ADAM10) and ADAM17 in a CD40 Protein-dependent Manner*
Background: CD154 is released from T-cells in a manner that remains elusive. Results: CD154 is released from Jurkat E6.1 T-cells by ADAM10 and ADAM17 upon its interaction with CD40 exclusively.Expand
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Essential role of protein kinase C delta in platelet signaling, alpha IIb beta 3 activation, and thromboxane A2 release.
The protein kinase C (PKC) family is an essential signaling mediator in platelet activation and aggregation. However, the relative importance of the major platelet PKC isoforms and their downstreamExpand
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Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression
Staphylococcal enterotoxin A (SEA) has two distinct binding sites for major histocompatibility complex (MHC) class II molecules. The aspartic acid located at position 227 (D227) in the COOH terminusExpand
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CD20 is physically and functionally coupled to MHC class II and CD40 on human B cell lines
Engagement of MHC class II and CD40 on B cell lines triggers intracellular signals that activates cell surface adhesion receptors, resulting in LFA‐1‐dependent and ‐independent cell‐cell adhesion. InExpand
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CD40 associates with the MHC class II molecules on human B cells
The MHC class II and CD40 molecules are two major components of the immune system that are involved in cell‐cell interactions and signal transduction. Data obtained in the course of the presentExpand
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