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Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells
Strong evidence is obtained that FDCs themselves produce PrP and that replication of a mouse-passaged scrapie strain in spleen depends on PrP-expressing F DCs rather than on lymphocytes or other bone marrow-derived cells. Expand
Impact of localized badger culling on tuberculosis incidence in British cattle
Results from a large-scale field trial indicate that localized badger culling not only fails to control but also seems to increase TB incidence in cattle. Expand
Positive and negative effects of widespread badger culling on tuberculosis in cattle
It is shown that, as carried out in this experiment, culling reduces cattle TB incidence in the areas that are culled, but increases incidence in adjoining areas, which is biologically consistent with previous studies but will present challenges for policy development. Expand
Host susceptibility to African trypanosomiasis: trypanotolerance.
This chapter discusses the available information on the aspects of trypanotolerance, with regard to cattle, sheep, goats, wildlife, and man, and describes experimental results derived from mouse models and the relevance of these models to trypanosomiasis of livestock. Expand
Molecular characterization of the WC1 antigen expressed specifically on bovine CD4-CD8- gamma delta T lymphocytes.
The isolation of a full length cDNA clone, encoding the WC1 Ag, from a COS cell cDNA expression library prepared from a bovine gamma delta T cell line provides a starting point for the definition of its role in gammaDelta T cell biology. Expand
A Novel Core Genome-Encoded Superantigen Contributes to Lethality of Community-Associated MRSA Necrotizing Pneumonia
A novel SAg staphylococcal enterotoxin-like toxin X (SElX) encoded in the core genome of 95% of phylogenetically diverse S. aureus strains is found, providing new insights into the evolution of pathogenic S.Aureus and the molecular basis for severe infections caused by the CA-MRSA USA300 epidemic clone. Expand
Bovine γ/δ TcR+ T Lymphocytes are Stimulated to Proliferate by Autologous Theileria annulata‐Infected Cells in the Presence of Interleukin‐2
An in vitro model system has been developed in which freshly isolated resting WC1+γ/δTcR+ T cells proliferate in response to cells transformed by the protozoan parasite Theileria annulata, providingExpand
Culling and cattle controls influence tuberculosis risk for badgers
It is shown that repeated badger culling in the same area is associated with increasing prevalence of M. bovis infection in badgers, which suggests that infection may be transmitted from cattle to badger, as well as vice versa, highlighting the need for policymakers to consider multiple transmission routes when managing multihost pathogens. Expand
Herd-level risk factors associated with tuberculosis breakdowns among cattle herds in England before the 2001 foot‐and‐mouth disease epidemic
The strongest factors associated with an increased TB risk were movement of cattle onto the farm from markets or farm sales, operating a farm over multiple premises and the use of either covered yard or ‘other’ housing types. Expand
Susceptibility of inbred strains of mice to Trypanosoma congolense: correlation with changes in spleen lymphocyte populations.
The findings suggested that the level of parasitaemia in different strains of mice may reflect differences in the nature of quality of the immune response to the trypanosome, and that the relative resistance of this strain is inherited as a dominant trait. Expand