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A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents
TLDR
The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses. Expand
Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
Oligomers of N-substituted glycines, or “peptoids“, represent a new class of polymers (Figure 1) that are not found in nature, but are synthetically accessible and have been shown to possessExpand
Measuring diversity: experimental design of combinatorial libraries for drug discovery.
TLDR
New methods to quantify molecular diversity using descriptors that characterize lipophilicity, shape and branching, chemical functionality, and specific binding features are described and quantify the overall diversity accessible to different families of combinatorial chemistry. Expand
Proteolytic studies of homologous peptide and N-substituted glycine peptoid oligomers
Abstract Homologous L-amino acid, D-amino acid, and parallel and anit-parallel (retro) sequence N-substituted glycine peptide and peptoid oligomers were prepared and incubated with proteases fromExpand
Comparison of the proteolytic susceptibilities of homologous L‐amino acid, D‐amino acid, and N‐substituted glycine peptide and peptoid oligomers
A series of homologous L‐amino acid, D‐amino acid, and both parallel and anti‐parallel (retro) sequence N‐substituted glycine peptide and peptoid oligomers were prepared and incubated with a seriesExpand
Development of 17α‐Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study
TLDR
Positive safety and pharmacokinetic data from a successful phase I clinical study with oral 17α‐E2 (sodium sulfate conjugate) are presented here, and several options for its future clinical assessment are discussed. Expand
Evaluation in rats of the somnogenic, pyrogenic, and central nervous system depressant effects of muramyl dipeptide
TLDR
At approximately equisomnogenic doses, MDP produced less potentiation of ethanol-induced loss of righting reflex than triazolam, indicating it produces less non-specific central nervous system depressant effects. Expand
Defining the mandate of proteomics in the post-genomics era: workshop report.
TLDR
The mandate of proteomics is and should be much broader than is frequently recognized and it is much more complicated than sequencing genomes, which will require new technologies but it is highly likely that many of these will be developed. Expand
N6-cycloalkyladenosines. Potent, A1-selective adenosine agonists.
TLDR
Mise en evidence de l'activite de reception adenosiniques A 1 de the N 6 -cyclopentyladenosine d'un serie de N 6-cycloalkylADenosines. Expand
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