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The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse
Overall, RHA1 appears to have evolved to simultaneously catabolize a diverse range of plant-derived compounds in an O2-rich environment and is established as an important model for studying actinomycete physiology. Expand
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages
The results suggest that cholesterol metabolism is central to M. tuberculosis's unusual ability to survive in macrophages and provide insights into potential targets for novel therapeutics. Expand
The lung tissue microbiome in chronic obstructive pulmonary disease.
There is a detectable bacterial community within human lung tissue that changes in patients with very severe COPD. Expand
Microbial reductive dehalogenation.
A wide variety of compounds can be biodegraded via reductive removal of halogen substituents. This process can degrade toxic pollutants, some of which are not known to be biodegraded by any otherExpand
The Actinobacterial mce4 Locus Encodes a Steroid Transporter*
There is direct evidence that the Mce4 system of Rhodococcus jostii RHA1 is a steroid uptake system, and Bioinformatic analysis revealed that all mce4 loci in sequenced genomes are linked to steroid metabolism genes, predicting that all Mce 4 systems are steroid transporters. Expand
Early infancy microbial and metabolic alterations affect risk of childhood asthma
It is reported in a longitudinal human study that infants at risk of asthma have transient gut microbial dysbiosis during the first 100 days of life, and certain bacterial genera were decreased in these children, suggesting a potential causative role of the loss of these microbes. Expand
Microbial community dynamics in a seasonally anoxic fjord: Saanich Inlet, British Columbia.
A robust comparative phylogenetic framework for inferring systems metabolism of nitrogen, carbon and sulfur cycling within oxygen-deficient oceanic waters is provided and Saanich Inlet is established as a tractable model for studying the response of microbial communities to changing levels of water column hypoxia. Expand
Killing two birds with one stone: simultaneous extraction of DNA and RNA from activated sludge biomass
This method combines mini-bead beating, which is most efficient in breaking bacterial aggregate flocs and cells, with protection of RNA with diethyl pyrocarbonate, and precipitation of impurities with ammonium acetate to allow simultaneous DNA and RNA extraction from activated sludge samples. Expand
An Inducible Propane Monooxygenase Is Responsible for N-Nitrosodimethylamine Degradation by Rhodococcus sp. Strain RHA1
It is demonstrated that propane monooxygenase is responsible for NDMA degradation by RHA1 and explain the enhanced cometabolic degradation of NDMA in the presence of propane. Expand
Bacterial, archaeal and eukaryal community structures throughout soil horizons of harvested and naturally disturbed forest stands.
The effects of organic matter removal and soil compaction on microbial community structures in different soil horizons 13 years after timber harvesting at the long-term soil productivity site at Skulow Lake, British Columbia are assessed. Expand