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The complete genome of Rhodococcus sp. RHA1 provides insights into a catabolic powerhouse
- M. P. McLeod, R. Warren, L. Eltis
- Biology, EngineeringProceedings of the National Academy of Sciences
- 17 October 2006
Overall, RHA1 appears to have evolved to simultaneously catabolize a diverse range of plant-derived compounds in an O2-rich environment and is established as an important model for studying actinomycete physiology.
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages
- R. van der Geize, Katherine C. Yam, L. Eltis
- BiologyProceedings of the National Academy of Sciences
- 6 February 2007
The results suggest that cholesterol metabolism is central to M. tuberculosis's unusual ability to survive in macrophages and provide insights into potential targets for novel therapeutics.
The lung tissue microbiome in chronic obstructive pulmonary disease.
- Marc A. Sze, P. Dimitriu, J. Hogg
- Biology, MedicineAmerican journal of respiratory and critical care…
- 15 May 2012
There is a detectable bacterial community within human lung tissue that changes in patients with very severe COPD.
Early infancy microbial and metabolic alterations affect risk of childhood asthma
- M. Arrieta, Leah T Stiemsma, B. Brett Finlay
- Medicine, BiologyScience Translational Medicine
- 30 September 2015
It is reported in a longitudinal human study that infants at risk of asthma have transient gut microbial dysbiosis during the first 100 days of life, and certain bacterial genera were decreased in these children, suggesting a potential causative role of the loss of these microbes.
Microbial reductive dehalogenation.
A wide variety of compounds can be biodegraded via reductive removal of halogen substituents. This process can degrade toxic pollutants, some of which are not known to be biodegraded by any other…
The Actinobacterial mce4 Locus Encodes a Steroid Transporter*
There is direct evidence that the Mce4 system of Rhodococcus jostii RHA1 is a steroid uptake system, and Bioinformatic analysis revealed that all mce4 loci in sequenced genomes are linked to steroid metabolism genes, predicting that all Mce 4 systems are steroid transporters.
Early life antibiotic‐driven changes in microbiota enhance susceptibility to allergic asthma
Data support a neonatal, microbiota‐driven, specific increase in susceptibility to experimental murine allergic asthma, consistent with the ‘hygiene hypothesis’.
Microbial community dynamics in a seasonally anoxic fjord: Saanich Inlet, British Columbia.
- E. Zaikova, D. Walsh, Claire Stilwell, W. Mohn, P. Tortell, S. Hallam
- Environmental ScienceEnvironmental microbiology
A robust comparative phylogenetic framework for inferring systems metabolism of nitrogen, carbon and sulfur cycling within oxygen-deficient oceanic waters is provided and Saanich Inlet is established as a tractable model for studying the response of microbial communities to changing levels of water column hypoxia.
Long-term warming alters the composition of Arctic soil microbial communities.
- J. Deslippe, M. Hartmann, S. Simard, W. Mohn
- Environmental ScienceFEMS microbiology ecology
- 1 November 2012
The shifts in soil microbial community structure appear sufficient to account for warming-induced changes in nutrient cycling in Arctic tundra as climate warms.
Bacterial, archaeal and eukaryal community structures throughout soil horizons of harvested and naturally disturbed forest stands.
- M. Hartmann, Sangwon Lee, S. Hallam, W. Mohn
- Biology, MedicineEnvironmental microbiology
- 1 December 2009
The effects of organic matter removal and soil compaction on microbial community structures in different soil horizons 13 years after timber harvesting at the long-term soil productivity site at Skulow Lake, British Columbia are assessed.